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The Transatlantic Think-Tank of Toxicology: t4

In June 2007, the National Academy of Science (NAS) released its report, Toxicity Testing and Assessment in the Twenty-first Century: A Vision and a Strategy. This report advocates sweeping and transformative changes in regulatory toxicity testing, and is a reflection of CAAT’s ideas, as it envisages a shift from current whole-animal based systems to testing founded primarily on in vitro methods, human cells in culture, in silico biokinetic modeling, and mechanisms of toxicity as understood through systems biology. Toxicity Testing and Assessment in the Twenty-first Century is essentially a roadmap for the future, representing a shift in the current testing paradigm by advocating the utilization of high-throughput, in vitro test methods and in silico modeling techniques that focus on human rather than animal biology.
 
On February 14, 2008, the Environmental Protection Agency (EPA), the National Toxicity Program (NTP), and the National Institutes of Health (NIH) signed a memorandum of understanding (MOU) to develop and implement new high-throughput, in vitro methods for testing chemicals and drugs. Based on the recommendations of the NAS report, this MOU will allow the collection of data requested in the NAS report. This significant step toward US development of alternative methodologies reflects both the best science and the most humane science.
 
To help implement the recommendations of the NAS report as quickly as possible, the Doerenkamp-Zbinden Foundation (DZF) and CAAT are collaborating to establish the Transatlantic Think Tank of Toxicology, or t4.  The t4 includes leaders in the field of evidence-based toxicology and alternatives from the University of Konstanz (Prof. Marcel Leist) and Utrecht University (Prof. Bas Blaauboer), as well Drs. Hartung and Goldberg from Johns Hopkins University. These four “ambassadors” of t4 will prepare and or commission high-quality analyses of toxicological problems and orchestrate a series of workshops, reports, and review papers designed to bring to fruition the innovative approaches outlined in the NAS report. The first t4 report, Re-evaluation of Animal Numbers and Costs for In Vivo Tests to Accomplish REACH Legislation Requirements for Chemicals, was released in August, 2009. A complete list of t4 publications can be found in ALTEX.

New ALTEX: 1/2016

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MeetingS

 
Promoting Dialogue Between In Vivo, In Vitro, and In Silico
May 18, 2016
Milan, Italy
mailto:acu@marionegri.it

SOT In Vitro and Alternatives Methods Speciality Section Grad Student and Postdoc Webinar
May 18, 2016
11am EDT

Mucosal Immunity and In Vitro Science
May 19, 2016
Milan, Italy

CAAT Academy: In Silico Modeling and Tools Under REACH 
May 20, 2016
Hosted by ROCAM in Cluj, Romania
Registration and Information

ACTC 2016 Conference
May 30-June 1, 2016
Barcelona, Spain

Kirkstall Workshop
June 2-3, 2016
Barcelona, Spain
oana.voloaca@kirkstall.org

CAAT Academy: Animal-free Pyrogenicity and Endotoxin Testing Under the New EU Pharmacopeia Chapter 5.1.10
June 8th, 2016
Konstanz, Germany 
 
17th International Conference on QSAR in Environmental and Health Sciences (QSAR 2016)
June 13-17, 2016
Miami Beach, Florida

17th Annual Congress of EUSAAT/20th European Congress on Alternatives to Animal Testing
August 24-27, 2016
University of Linz, Austria

ESTIV 2016 Congress: In Vitro Toxicology for Human Safety Assessment
October 17-20, 2016
Juan-les-Pins, France

AALAS 67th Annual Meeting
October 30-November 3, 2016
Charlotte, NC

SAVE THE DATE:
10th World Congress on Alternatives and Animal Use in the Life Sciences
August 20-24, 2017
Seattle, Washington
 

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