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ALTEX: Current Issue 2013: Vol 30, No. 3

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(All Articles are in PDF)

Editorial
Sonja von Aulock

FOOD FOR THOUGHT

Thomas Hartung:
Look back in anger – what clinical studies tell us about preclinical work

MAIN ARTICLES

Barae Jomaa, Jac M. M. J. G. Aarts, Laura H. J. de Haan, Ad A. C. M. Peijnenburg, Toine F. H. Bovee, Albertinka J. Murk, and Ivonne M. C. M. Rietjens:
In vitro pituitary and thyroid cell proliferation assays and their relevance as alternatives to animal testing

Sebastian Polak:
In vitro to human in vivo translation – pharmacokinetics and pharmacodynamics of quinidine
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upplement

Karin Dreisig, Camilla Taxvig, Mia Birkhøj Kjærstad, Christine Nellemann, Ulla Hass, and Anne Marie Vinggaard:
Predictive value of cell assays for developmental toxicity and embryotoxicity of conazole fungicides
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upplement

Miriam N. Jacobs, Susan C. Laws, Kate Willett, Pat Schmieder, Jenny Odum, and Toine F. Bovee:
In vitro metabolism and bioavailability tests for endocrine active substances: What is needed next for regulatory purposes?

t4 WORKSHOP REPORT

Louise Parks Saldutti, Bruce K. Beyer, William Breslin, Terry R. Brown, Robert E. Chapin, Sarah Campion, Brian Enright, Elaine Faustman, Paul M. D. Foster, Thomas Hartung, William Kelce, James H. Kim, Elizabeth G. Loboa, Aldert H. Piersma, David Seyler, Katie J. Turner, Hanry Yu, Xiaozhong Yu, and Jennifer C. Sasaki:
In vitro testicular toxicity models: Opportunities for advancement via biomedical engineering techniques
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upplement

WORKSHOP REPORT

Francesca Caloni, Patrizia Costa, Gianni Dal Negro, Isabella De Angelis, Silvia Dotti, Giovanna Lazzari, Giacomo Metteucci, and Augusto Vitale:
Alternative Methods: 3Rs, Research and Regulatory Aspects

COMMENT

Daniel R. Dietrich, Sonja von Aulock, Hans Marquardt, Bas Blaauboer, Wolfgang Dekant, James Kehrer, Jan Hengstler, Abby Collier, Gio Batta Gori, Olavi Pelkonen, Florian Lang, Frans P. Nijkamp, Kerstin Stemmer, Albert Li, Kai Savolainen, A. Wallace Hayes, Nigel Gooderham, and Alan Harvey:
Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Federico M. Stefanini:
Bayesian Network Integrated Testing Strategy and beyond

Joanna Jaworska:
Reply to: Bayesian Network Integrated Testing Strategy and beyond

ERRATUM

Nina Hasiwa, Mardas Daneshian, Peter Bruegger, Stefan Fennrich, Astrid Hochadel, Sebastian Hoffmann, Felix E. Rivera-Mariani, Christoph Rockel, Stefanie Schindler, Ingo Spreitzer, Sandra Stoppelkamp, Kranthi Vysyaraju, and Thomas Hartung:
Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

New ALTEX: 3/2014

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