the global clearinghouse for information on alternatives to animal testing

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Featured Items:

Evidence-based Toxicology Collaboration Kick-off Meeting. ALTEX 28: 152.

Markers of murine embryonic and neural stem cells, neurons and astrocytes:  reference points for developmental neurotoxicity testing: a Transatlantic Think Tank of Toxicology (t⁴) Review (from ALTEX 1/2010)

Food for Thought. . . on alternative methods for chemical safety testing (Thomas Hartung, ALTEX 1/2010)

Nature papers and other articles calling for an urgent review of REACH legislation (Hartung & Rovida)

• Data Gaps Threaten Chemical Safety Law (Nature News, July 2011)
• Re-evaluation of Animal Numbers and Costs for In Vivo Tests to Accomplish REACH Legislation Requirements for Chemicals—a Report by the Transatlantic Think Tank of Toxicology (t4)
  (Thomas Hartung and Costanza Rovida, ALTEX 3/09)
  
• Chemical regulators have overreached (Nature)
• Chemical-safety costs uncertain (Nature News)
  
• Has REACH over-reached? (Nature Podcast)
• Nature Network Opinion Forum: Chemical testing in Europe
• EU chemicals law "spells surge in animal testing" (Reuters)

Other Articles:

• Food for thought ... A replacement-first approach to toxicity testing is necessary to successfully reauthorize TSCA 
• Food for thought ... Can case study approaches speed implementation of the NRC report: “Toxicity Testing in the 21st Century: A Vision and a Strategy?” (Issue 11/03)
• Food for thought … on mapping the human toxome (Issue 11/02)
  
• Food for thought … on validation. A puzzle or a mystery: an approach founded on new science. (Issue 11/01)
• Food for thought...considerations and guidelines for basic test method descriptions in toxicology. (Issue 4/10)
• Food for thought…why no new in vitro tests will be done for REACH by registrants. (Italian language version, PDF) (Issue 3/10)
• Food for thought…on alternative methods for nanoparticle safety testing. (Issue 2/10)
• Food for thought...on alternative methods for chemical safety testing. (Issue 1/10)
• Food for thought...on education in alternative methods in toxicology.  (Italian language version, PDF) (Issue 4/09)
• Food for thought . . . on in silico methods in toxicology (from ALTEX 3/09)
• Toxicology for the Twenty-first Century (Nature article by CAAT Director Thomas Hartung)
• Food for thought . . . on evidence based toxicology (from ALTEX 2/09)
  PDF version
• CAATfeed (news updates from CAAT)

For Scientists and Researchers:

• Search for Alternatives: A Comprehensive Guide to Alternatives Searches
• IACUCS and Animal Ethics Committees Resources

For Students:

• Frequently Asked Questions (FAQs): Want to know more about alternatives to animal experiments? Writing a paper on the topic? Start here.
• The Principles of Humane Experimental Technique by Russell and Burch. Full text of the classic publication that created the 3Rs.
• Video: 25 Years of Humane Science (documentary about CAAT)

For Everyone:

• Altweb launches new 3Rs and Alternatives Organizations website.
• Video from Thomas Hartung's presentation at the 2011 Annual Meeting of the Society of Toxicology: "From Alternative Methods to a New Toxicology for the 21st Century."