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SPECIAL SECTION: MONOCLONAL ANTIBODIES
REPORTS AND PROCEEDINGS
Monoclonal antibodies have been the subject of a variety of discussions and meetings, including four major scientific conferences since 1996. Though the meetings differed somewhat in purpose and composition, they mostly agreed in their conclusions: (1) the ascites method of MABs production is associated with pain and distress for the animals; (2) a wide variety of in vitro methods now are available that can produce MABs of comparable quality, quantity, and cost to the ascities method; and (3) these in vitro methods should be used whenever possible. The full discussions and conclusions are presented in the readings that follow.
Proceedings of the Production of Monoclonal Antibodies Workshop. Aug. 1999. Edited by J. E. McArdle and C J. Lund. Alternatives Research and Development Foundation.
Comparison of CAAT, ECVAM, and ILAR reports on monoclonal antibody production. Peter Theran. In: Proceedings of the Production of Monoclonal Antibodies Workshop. Aug. 1999. Edited by J. E. McArdle and C J. Lund. Alternatives Research and Development Foundation.
ILAR report on Monoclonal Antibody Production. A Report of the Committee on Methods of Producing Monoclonal Antibodies. Institute for Laboratory Animal Research, National Research Council. 1999.
(PDF file)
CAAT Technical Report # 8: Alternatives in Monoclonal Antibody Production. Sept. 1997.
Proceedings for CAAT workshop on Alternatives in Monoclonal Antibody Production, Sept. 24-25, 1997.
The Report and Recommendations of ECVAM workshop 23: Monoclonal Antibody Production. Nov. 1996.
See also the Books and Proceedings section of the AWIC site.