Skip Navigation



The amount of MAB needed varies with the intended use. Most research projects and many analytic purposes require only small amounts of a MAB (< 0.1 g). Larger quantities are necessary for routine diagnostic procedures and for therapeutic purposes. Commercial biotechnology companies now handle most of the large-scale production, typically using in vitro methods. Small-scale production in individual research labs accounts for most use of the ascites method these days.

Core centers, located at academic institutions, offer a good alternative for researchers needing small MAB amounts. These are not-for-profit, centralized facilities that offer specialized laboratory services to investigators on a fee-for-service basis. Many are at least partially funded by the National Institutes of Health. Using a core laboratory can provide a more cost-effective way for many investigators to use MABs produced by in vitro methods.

The listings below provide contact information for suppliers of in vitro monoclonal antibodies, including both commercial companies and core laboratories. There may be some overlap among the various lists.

ARDF Resource List of In Vitro MAB Producers.

Johns Hopkins Genetic Resources Core Facility Cell Center

CAAT list of Core Facilities, with contact information.

Small-scale monoclonal antibody production in vitro: Methods and resources. L. Jackson, L. Trudel, and N. Lipman. In: Proceedings of the Production of Monoclonal Antibodies Workshop. Aug. 1999. Edited by J. E. McArdle and C J. Lund. Alternatives Research and Development Foundation.

University of California Center for Animal Alternatives (UCCAA) web site. MABs section: Companies and Core Facilities.

AWIC Information Resources for Adjuvant and Antibody Production: Comparisons and Alternative Technologies (1990-97): Companies and Institutes.

Antibody Resource Page

The Nature Biotechnology Directory

Core laboratories: What is their cost-effectiveness and what are their needs? Margaret Penno. In: CAAT Technical Report #8: Alternatives in Monoclonal Antibody Production. Sept. 1997.


New ALTEX: 3/2017
ALTEX 3/2017 cover

Support ALTWEB, Make a Gift
Online Humane Science Course


FRAME Training School in Experimental Design and Statistical Analysis
May 31-June 2, 2017
Saskatoon, Canada

Advances in Cell and Tissue Culture 2017
May 22-24, 2017
Manchester, UK

CAAT Academy
In Vitro Skin and Eye Models Hands-on Training
June 1-2 2017
Brussels, Belgium

CAAT Academy
Tools for Read-Across
June 15-16, 2017
Helsinki, Finland

ecopa SSCT Workshop 2017
June 14-16, 2017
Helsinki, Finland
Thomas Hartung will deliver a keynote address

CAAT Academy
Updates on Hepatotoxicity AOP Landscape and on the ADME Field - Season 2
June 22-23, 2017
Rennes, France

9th Euro-Global Summit on Toxicology and Applied Pharmacology
June 22-24, 2017
Paris, France
Email for Details

6th Annual Meeting of the American Society for Cellular and Computational Toxicology (ASCCT)
September 21-22
College Park, MD

10th World Congress on Alternatives and Animal Use in the Life Sciences
August 20-24, 2017
Seattle, Washington

CAAT Academy
Hands-on Training in Quantitative Human Cell and Effect-based In Vitro Bioanalysis for Assessing Endocrine-disrupting Compounds (EDCs)
September 7-8. 2017

More Meetings...