Proceedings for Pain Management and Humane Endpoints

A workshop of
The Johns Hopkins Center for Alternatives to Animal Testing
National Institutes of Health Office for Protection from Research Risks
The National Institutes of Health Office for Animal Care and Use
and
The National Academy of Sciences Institute for Laboratory Animal Research

November 2-3, 1998
National Academy of Sciences Auditorium
2101 C Street, NW
Washington, DC

INTRODUCTION AND WELCOME

Ralph B. Dell, ILAR, NAS

OVERVIEW OF ISSUE

Science
Gerald F. Gebhart, University of Iowa
Philosophical and Ethical Issues Concerning Pain
David DeGrazia, George Washington University

Opinion Research on Animal Experimentation: Areas of Support and Concern
Scott Plous, Wesleyan University

SCIENCE

Assessment of Pain and Distress in Laboratory Animals
Jeri Sechzer, Pace University and UMDNJ

Pain Assessment in Children
Charles B. Berde, Children's Hospital, Boston

Alleviation of Pain in Laboratory Animals
Paul Flecknell, University of Newcastle, UK

Alleviation of Animal Pain: Clinical Applications
Dennis R. Geiser, University of Tennessee--presenting for Charles Short

Arriving at a Biological Definition of Stress and Distress
Gary Moberg, University of California at Davis

POLICY

Pain Management and Humane Endpoints: PHS Policy Perspective
Nelson L. Garnett, NIH, OPRR

Animal Welfare Act--Requirements for the Minimization of Pain and Distress
W. Ron DeHaven, USDA, APHIS

Multinational Agreements/International Harmonization
John G. Miller, AAALAC International

The Triple A Approach to Assure Animal Welfare
Judith Davis, AHCS, DIR, NINDS, NIH

Animal Welfare Perspectives on Pain and Distress Management in Research and Testing
Andrew N. Rowan, Humane Society of the United States

IACUC and Pain-Related Internet Resources
Kenneth R. Boschert, Washington University

IMPLEMENTATION

IACUC Responsibilities: Reviewing Potentially Painful Procedures
Ralph B. Dell, ILAR/NAS

Implementing Assessment Techniques David B. Morton, University of Birmingham, UK

ENDPOINTS

Canadian Council on Animal Care Guidelines on: Choosing an Appropriate Endpoint in Experiments Using Animals in Research Teaching and Testing
Jim H. Wong, Canadian Council on Animal Care

Endpoints in Infectious Disease and Cancer Models
Ernest Olfert, University of Saskatchewan, Canada

Monitoring of Genetic Engineering Studies
Melvin B. Dennis, Jr., University of Washington

Humane Endpoints for Laboratory Animals Used in Toxicology Testing
William S. Stokes, NIEHS/ICCVAM

PANEL DISCUSSION--Q&A

Humane Endpoints in the OECD--An Update
Alan M. Goldberg JHU, CAAT