OCTOBER 2004 NEWS

In Vitro Protocols for Estimating Acute Oral Systemic Toxicity/Request for Data

The National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) announced the availability of "Updated Standardized In Vitro Cytotoxicity Test Method Protocols for Estimating Acute Oral Systemic Toxicity" and issued a request for in vivo and in vitro acute toxicity data in the Federal Register today.

A copy of the FR notice can be found in PDF or in HTML.

The in vitro cytotoxicity test method protocols will be used to estimate acute oral systemic toxicity in rodents. These two test methods have been recommended by the ICCVAM for selecting starting doses for in vivo acute oral systemic toxicity tests (Federal Register, September 28, 2001) in order to reduce the number of animals required for acute oral toxicity testing. NICEATM also requests the submission of data on chemicals and products tested for both acute oral systemic toxicity and in vitro cytotoxicity using the standardized test method protocols mentioned in this notice. These data will be used to further evaluate the usefulness and limitations of cytotoxicity methods for estimating in vivo acute oral toxicity and support the investigation of other test methods necessary to improve the accuracy of in vitro assessments of acute systemic toxicity.

Please submit data to:

NICEATM
Dr. William S. Stokes, Director
NICEATM NIEHS
PO Box 12233, MD EC-17
Research Triangle Park, NC 27709
(phone) 919-541-2384
(fax) 919-541-0947
(e-mail) iccvam@niehs.nih.gov

The ICCVAM and NICEATM web site is located at:
http://iccvam.niehs.nih.gov/

For more information on acute oral toxicity, please visit the in vitro test methods page.