MARCH 2006 NEWS

ICCVAM to Hold Peer Review Meeting on In Vitro Acute Systemic Toxicity Test Methods

Notice of public meeting for a scientific peer review of the use of two in vitro basal cytotoxicity test methods for estimating starting doses for in vivo acute oral toxicity tests was published in the Federal Register today (Vol. 71, No 54, pp 14229-30). The in vitro methods are proposed as adjuncts to in vivo acute oral toxicity tests to reduce and refine (i.e. lessen or avoid pain or distress) animal use. This notice can be found in PDF at http://iccvam.niehs.nih.gov/docs/FR/7114229.pdf or in HTML at http://iccvam.niehs.nih.gov/docs/FR/7114229.htm.

The scientific peer review will take place on Tuesday, May 23, 2006, from 8:30 a.m. to 5:00 p.m., at the National Institutes of Health (NIH), Natcher Center, Bethesda, MD. The meeting is open to the public with attendance limited only by the space available. Go to this page for online or downloadable fax registration forms.

NICEATM has prepared a Background Review Documents (BRD) on the two NRU test methods, which can be viewed at this page. This document can also be accessed from the ICCVAM home page at http://iccvam.niehs.nih.gov/ the links in the "Announcements" box. For more information on this method, visit the In Vitro Acute Toxicity page at http://iccvam.niehs.nih.gov/methods/invitro.htm.