Skip Navigation

Artery-on-a-Chip Studies Heart Disease

Scientists from Canada have developed a microfluidic platform on which fragile blood vessels can be fixed, allowing the factors that promote and sustain cardiovascular diseases to be studied.

Microvascular structure and function are currently studied using either an isometric approach, where small arteries are mounted on two wires, or an isobaric method, where arteries are drained and filled using glass micropipettes. Both of these procedures require manually skilled personnel and are not scalable - key factors which have limited the number of laboratories carrying out essential microvascular research.

However, Axel Günther and colleagues at the University of Toronto have overcome several of these limitations by developing a microfluidic platform to mount arteries on, which is scalable, inexpensive and has potential for automation and standardisation. The device could be used to routinely screen drug candidates on viable arteries, potentially speeding up the drug development process and reducing the need for animal experimentation.

More at link

New ALTEX: 2/2018

ALTEX cover 51

Support ALTWEB, Make a Gift
Online Humane Science Course


Building a Better Epithelium: Breaking the Barrier to the Next Generation of Toxicity Testing
March 10, 2018
San Antonio, TX

SOT Satellite Meeting: Updates on Activities Related to 21st Century Toxicology and Related Efforts: Invited Presentations and Open Mic
March 15, 2018
San Antonio, TX

Social Housing Workshop
June 4-5, 2018
Beltsville, MD

2nd Pan-American Conference for Alternative Methods
August 23-24, 2018
Rio de Janeiro, Brazil 

Eurotox 2018
September 2-5, 2018
Brussels, Belgium

20th International Congress on In Vitro Toxicology (ESTIV2018)
October 15-18, 2018

More Meetings...