ICCVAM Develops Recommended Performance Standards for LLNAThe LLNA was the first alternative test method evaluated and recommended by ICCVAM. Based on the recommendations of ICCVAM and an independent scientific review panel, the LLNA has been accepted by U.S. and international regulatory authorities as a stand-alone test method for assessing the potential of a substance to induce allergic contact dermatitis. ICCVAM currently routinely develops performance standards for test methods.Before a new test method is accepted for regulatory testing applications,
validation studies are conducted to assess its reliability (i.e., the extent of intra- and inter-laboratory reproducibility), and its relevance (i.e.,the ability of the test method to correctly predict or measure the biological effect of interest, which is partly dependent on the accuracy of the test method). Performance standards communicate the basis by which new proprietary (i.e.,copyrighted, trademarked, registered) and nonproprietary test methods have been determined to have sufficient accuracy and
reliability for a specific testing purpose. These performance standards can then be used to evaluate the accuracy and reliability of other proposed test methods that are considered functionally and mechanistically similar to the accepted test method.
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