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Human on a Chip (Fast Company)

Excerpt:

Advocates like Pascaline Clerc, a senior director at the Humane Society of the United States and a former cellular biologist whose work once involved lab work on animals, view the organ-on-a-chip work at Wyss as among the most promising of several advances aimed at reducing or eventually replacing animal testing.

Yet while quite impressed with the progress so far, Thomas Hartung, director of the Center for Alternatives to Animal Testing at the Johns Hopkins Bloomberg School of Public Health, notes there will be many challenges in getting a “reasonably completely model of a human system” right.

“There’s a certain hype at the moment because a lot of money was made available for this,” he says. “The body is incredibly efficient. It’s very difficult to reproduce this.”

Hartung is leading a project that takes the opposite approach. Rather than trying to reproduce the complexity of the human system, The Human Toxome Project is working to break it down into its simplest elements. Starting with endocrine disruption, the chemicals that interfere with the body’s hormonal system, his team is beginning to model the ways in which the body’s cells process the tens of thousands of chemicals that consumers are exposed to in their daily lives, many of which have never undergone health or toxicity testing. (EPA rarely requires companies to conduct toxicological tests for new chemicals before marketing their products. Out of some 28,000 “pre-marketing notifications,” the agency has requested testing about 200 times, says Hartung. “The are overwhelmed by the task.”)

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FRAME Training School in Experimental Design and Statistical Analysis
May 31-June 2, 2017
Saskatoon, Canada

Advances in Cell and Tissue Culture 2017
May 22-24, 2017
Manchester, UK

CAAT Academy
In Vitro Skin and Eye Models Hands-on Training
June 1-2 2017
Brussels, Belgium

CAAT Academy
Tools for Read-Across
June 15-16, 2017
Helsinki, Finland

ecopa SSCT Workshop 2017
June 14-16, 2017
Helsinki, Finland
Thomas Hartung will deliver a keynote address

CAAT Academy
Updates on Hepatotoxicity AOP Landscape and on the ADME Field - Season 2
June 22-23, 2017
Rennes, France

9th Euro-Global Summit on Toxicology and Applied Pharmacology
June 22-24, 2017
Paris, France
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6th Annual Meeting of the American Society for Cellular and Computational Toxicology (ASCCT)
September 21-22
College Park, MD

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10th World Congress on Alternatives and Animal Use in the Life Sciences
August 20-24, 2017
Seattle, Washington

CAAT Academy
Hands-on Training in Quantitative Human Cell and Effect-based In Vitro Bioanalysis for Assessing Endocrine-disrupting Compounds (EDCs)
September 7-8. 2017
Amsterdam
 

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