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Joint Information Day on “High Content Imaging Technology in Safety Sciences”

October 24, 2013
Mainz, Germany

Event flyer now available (PDF).

High Content Imaging (HCI) systems provide quantitative data from cellular assays involving automated microscopy and image analysis. These multi-parametric data sets refer to multiple endpoints and can be obtained from large numbers of cells with higher-throughput, in an observer-independent standardized way.

This information day will focus on the possibilities of the HCI technology for examination of damage mechanisms and toxic effects of chemicals. Probes for organelle and cell function and reporter systems for organ and systemic toxicity will be presented. The discussion will address questions on how phenotypic and signaling changes are linked to functional impairment and cell fate. Furthermore, the implementation of the HCI approach in (regulatory) safety sciences, latest technical advances and perspectives from the fields of systems biology/toxicology will be important topics during this event.

Presentations will be followed by a discussion period focused on addressing your individual questions. The complete program will be available soon on the CAAT and CAAT-EU websites.

Agenda:

09:00 - 09:15
Welcome Address

09:15 – 09:40
Prof. Marcel Leist, CAAT-Europe, University of Konstanz, Germany
"Unbiased Characterization of Cell Differentiation and Neurotoxicity"

09:40 - 10:05
Dr. Bill Mundy, U.S. Environmental Protection Agency, USA
"Screening Chemicals for Developmental Neurotoxicity: HCI Casts a Wide Net"

10:05 - 10:30
Prof. Bob de Water, Leiden University, The Netherlands
"A High-Throughput Imaging-based Pathways of Toxicity GFP-reporter Platform for Chemical Safety Assessment"

10:30 - 11:10
Coffee break

11:10 - 11:35
Dr. Peter Macko, EURL ECVAM, Italy
"Non-invasive HCI Methods for Studying Dynamic Cellular Processes and Bioenergetics"

11:35-12:00
Dr. Marianne Uteng, Novartis AG, Switzerland
"Mechanistic Insights into Mitochondrial Toxicity by High-Content Imaging"

12:00 - 13:00
Lunch and coffee

13:00-13:25
Dr. Eugenio Fava, German Center for Neurodegenerative Diseases (DZNE), Germany
"High-Content Analysis and Quantitative System Pharmacology in Compounds Prioritization"

13:25-13:50
Dr. Mario Beilmann, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany
"High-Content Imaging as a tool for Nonclinical Drug Safety investigations"

13:50-14:15
Dr. Anthony Davies; INCHSA, Trinity College Dublin, Ireland
"The Development in vivo Mimetic Bioreactor Technologies as a Basis for Improved in vitro Models for Drug Discovery and Safety Testing using High-Content Imaging Technologies"

14:15-14:45
Dr. Manfred Kansky, Dr. Stefan Kustermann, F. Hoffmann-La Roche AG, Switzerland
"High-Content Imaging for Early Safety Assessment of Drug Candidates at Roche"

14:45 - 15:15
Coffee break

15:15-15:40
Prof. Yvon Jule, Biocellvia, Université de Provence, Marseille, France
"Towards an HCI Analysis Approach for Evaluating the Efficacy and Toxicity of bioactive compounds using Histological Images of ex vivo Tissues and/or 3D in vitro Reconstructed Models"

15:40-16:05
Dr. Imran Shah, U.S. Environmental Protection Agency
"Using High-Content Screening to Reconstruct Cell State Dynamics Following Chemical Perturbation"

16:05-16:30
Roland Fleck, National Institute of Biological Standards and Control, UK
"Applications and Opportunities of High-Content Imaging for Biological Standardisation and Control"

16:30
Closing Remarks
Prof. Thomas Hartung, CAAT, Johns Hopkins University, USA

Presentations will be followed by a discussion to address questions from the audience

Meeting location:

Novotel Mainz
Augustusstraße 6
55131 Mainz
Germany
10:00 am – 04:00 pm.

Registration:

  • Free for CAAT Sponsors and associates as well as for federal agencies, students and NGO’s, € 100 after September 28th
  • € 300 early registration
  • € 500 after September 28th

To register, please contact CAAT-EU.

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