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Mini-Kidneys from Stem Cells Could Aid Toxicity Testing

In a time when organoids are becoming commonplace in the lab, a research team from Australia and the Netherlands has successfully generated structures that resemble embryonic kidneys from human stem cells. In addition to being a step in the right direction for eventual lab-grown kidneys for transplant, the structures could help scientists screen drugs for toxicity and model normal and diseased kidney function, the authors argue in Nature today (October 7).

“It’s not a kidney, it’s a kidney model,” study coauthor Melissa Little of the Murdoch Children’s ­Research Institute in Melbourne, Australia, told The Australian. “But it’s a hell of a lot better than we’ve had before.”

“The structure’s fine-scale tissue organization is realistic, but it does not adopt the macro-scale organization of a whole kidney,” Jamie Davies of the University of Edinburgh wrote in an accompanying commentary. “There is a long way to go until transplantable kidneys can be engineered, but [the new] protocol is a valuable step in the right direction."

Full Article at The Scientist

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MeetingS

 
Building a Better Epithelium: Breaking the Barrier to the Next Generation of Toxicity Testing
March 10, 2018
San Antonio, TX

SOT Satellite Meeting: Updates on Activities Related to 21st Century Toxicology and Related Efforts: Invited Presentations and Open Mic
March 15, 2018
San Antonio, TX

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Social Housing Workshop
June 4-5, 2018
Beltsville, MD
Email: kherrma1@jhu.edu

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2nd Pan-American Conference for Alternative Methods
August 23-24, 2018
Rio de Janeiro, Brazil 

Eurotox 2018
September 2-5, 2018
Brussels, Belgium

20th International Congress on In Vitro Toxicology (ESTIV2018)
October 15-18, 2018
Berlin
 

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