ECVAM 43: Table 1

Table I: Characterisation and comparison of various pyrogen tests

	Limit of detection (IU/ml)	Quantification	Accuracy	Precision	Robustness	Sensitivity/ specificity	Costs	Acceptance	Spectrum	Practicability	Standardisation
Rabbit pyrogen tests	± 0.5-3	-	n.a.	n.a.	+	+	-	-^a	+	-	-
Bacterial endotoxin tests	+ 0.03	+	+^b	+^b	±	±	+	+^a	-	±	+
In vitro pyrogen tests	+ 0.03-0.1	+	+	+	u.e.	+^c	+	+^a	+	±	u.e.

Overall judgement: + = positive, - = disadvantage, ± = intermediate.
n.a. = not applicable, ^apublic versus scientific opinion, ^bLPS only, ^cpredominantly artificial contamination, u.e. = under evaluation, 1IU = 100 pg.