Alternative Methods in Toxicology

Volume 6 - Progress in In Vitro Toxicology

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers

Preface

Acknowledgements

Contributing Authors

Part One: Sympopsium Presentations

Epidermal Toxicity
1. Skin Toxicity
  L.A. Goldsmith
2. Proteinase Biology in Keratinocyte Culture: Possible Utility as a Model for Toxicological Testing
  G.S. Lazarus
3. Testskin: A Hybrid Organism Covered by a Living Human Skin Equivalent DEsigned for Toxicity and Other Testing
  E. Bell, N.L. Parenteau, H.B. Haimes, R.J. Gay, P.D. Kemp, T.W. Fofonoff, V.S. Mason, D.T. Kagan, and M. Swiderek
4. Cellular Responses of Cultured Human Epidermal Keratinocytes as Models of Toxicity to Human Skin
  S.T. Boyce, J.F. Hansborough, and D.A. Norris
5. Surfactant-Induced Cutaneous Primary Irritancy: An In Vitro Model - Assay System Development
  V. DeLeo, J. Hong, S. Schiede, B. Kong, S. De Salva, and D. Bagley
6. Summary of Panel Discussion
  Y. Gressel
Recent Advances in Tissue Culture
1. Introduction
  P. Ward
2. Cultured Endothelial Cells as Probes for In Vitro Biology
  U.S. Ryan and J.M. Vann
3. Cultured Rat Hepatocytes in the Study of the Hepatoxicity of Acetaminophen
  J.L. Farber
Update: A Critical Evaluation of Alternatives to Acute Ocular Irritancy Testing
J.M. Frazier
Biotechnology and In Vitro Toxicology
1. Issues in the Dafety Assessment of Products of Biotechnology
  G. Zbinden
2. Recombitant DNA and Monoclonal Antibody Products
  R.E. Stoll
3. Tests for Worker Exposure to Products of Biotechnology
  D.K. Flaherty, P.A. Winzenburger, and P.L. Sherman
4. Summary
  R.A. Scala

Part 2: Poster Presentations

Poster Presentations
1. Functional Characteristics of Proximal Tubule Cells in Primary Culture: A New In Vitro Model for Studying Nephrotoxocity
  M.D. Aleo and P.J. Kostyniak
2. Structure-Activity Relationship of Inorganic Metals, Organometals, and Organic Test Agents Determined In Vitro with the Neutral Red Assay
  H. Babich and E. Borenfreund
3. An Imrproved CAM Assay for Predicting Ocular Irritation Potential
  D.M. Bagley, P.Y. Rizvi, B.M. Kong, and S.J. De Salva
4. The Effects of Hyperoxic and Hypoxic Exposure on Catalase in Mouse Skin Explants
  M.G. Bird, G. Witz, R.A. Scala, and D.V. Parke
5. Prediction of the Eye Irritation Potential of Surfactant-Based Household Cleaning Products Using the SIRC Cell Toxicity Test
  J. Demetrulias and H. North-Root
6. Differential Response of In Vitro Vaginal Tissue to Various Test Agents
  N.H. Dubin, R.B. Ghodgaonkar, and T.H. Parmley
7. Use of Isolated Hepatocytes for Studying the Biochemical Mechanisms of Steatosis and Cholestasis
  F. Goethals, D. Deboyser, C. Gonzalez, and M. Roberfroid
8. The Use of Freshly Isolated Hepatocytes for Studying Toxicity of Drug Mixtures
  F. Goethals, P. Vossen, M.-N. Blaude, and M. Roberfroid
9. Comparative Hazard Assessment of Formaldehyde and Trioxane In Vitro Using Human Diploid Cell Strains
  R.A. Kreiger and V.F. Garry
10. High Performance Liquid Chromatography Analysis of the Novel Neutrophil Chemoattractants "Nourin" Released from Alkali-Burned Corneas
  F. Metwally, A. Cohen, E.F. Rossomando, and S.A. Elgebaly
11. Acute and Protracted Injury to Corneal Epithelium as an Indication of the Biocompatibility of Various Pharmaceutical Vehicles
  D.R. Meyer and J.P. McCulley
12. In Vitro Toxicology Data on Respirable Particles and Fibres and Its Evaluation for Statistical Significance
  D. Nadeau, D. Paradis, L. Fouquette, and J. Dunnigan
13. In Vitro Ocular Irritancy Prediction: Assays in Serum-Free Media Correlate Better with In Vivo Data
  C. Shopsis and b. Eng
14. The MTT In VitroCytotoxicity Test: Correlation with Cutaneous Irritancy in Two Animal Models
  D.A. Swisher, M.E. Prevo, and P.W. Ledger
15. Trans-Epithelial Permeability of Fluorescein In Vitro as an Assay to Determine Eye Irritants
  R. Tcaho
16. In Vitro Cytotoxicity Test Using Primary Cells Derived from Rabbit Eye Is Useful as an Alternative for Draize Testing
  M. Watanabe, K. Watanabe, K. Suzuki, O. Nikaido, T. Sugahara, I. Ishii, and H. Konishi
17. Evaluation of Organic Nephrotoxins Using Rabbit Renal Cortical Slices
  G.H.I. Wolfgang, A.J. Gandolfi, C.L. Krumdieck, and K. Brendal
18. A Rapid and Reliable Acute Toxicity Test for Hepatotoxic Agents Using Only a Single Animal
  U. Wormser and D. Calp
Commercial Poster Presentations
1. The EYTEX-MPA System: An In Vitro Method for the Evaluation of Ocular Safety
  V.C. Gordon and H.C. Bergman
2. External Evaluation of the Standard EYTEX System in Six Laboratories to Determine Intra- and Inter-Laboratory Accuracy and Precision
  V.C. Gordon and H.C. Bergman
3. External Evaluation of the EYTEX and EYTEX-MPA Systems in Twelve Laboratories to Determine the Correlation of EYTEX Results with In Vivo Results
  V.C. Gordon and H.C. Bergman
4. Current Uses of Normal Human Epidermal Keratinocytes in Serum-Free Medium for In Vitro Toxicology
  P.T. Wagner

Alternative Methods in Toxicology

Volume 6 - Progress in In Vitro Toxicology

Series Editor: ALAN M. GOLDBERG

Table of Contents