ALTEX :: Alternatives to Animal Experiments

1994, Supplement

The Importance of Endotoxin Producing Bacterias for Practical Purposes

Dietrich Schimmel

Institut für Veterinärmedizin des Bundesgesundheitsamtes (Robert von Ostertag-Institut)-Bereich D-Jena

SUMMARY

Lipopolysaccharides (endotoxin) cause according to resorption out of the intestinal tract or aerogenic inhalation or by a septic infection clinical signs. The clinical reactions are praeshock symptoms, acute forms of shock and death. The experimental intratracheally administration of lipopolysaccharides into calves caused pneumonic lesions without bacterial experimental infection.

Keywords: lipopolysaccharides, endotoxin effects in animals