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ALTEX :: Alternatives to Animal Experiments
1999, VOLUME 3
Editorial
Horst Spielmann
CONTENTS :: MAIN ARTICLES
Progress in the Research of Atherosclerosis and Restenosis Using an in vitro Method: Transfilter Cocultures with Human Vascular Cells
Dorothea Ilse Siegel-Axel, Richard Viebahn, Eberhard Ludwig Betz, and Karl Rüdiger Karsch
Potency Testing of Swine Erysipelas Vaccines by Serology Results of a Pre-Validation Study
Ute Rosskopf-Streicher, Heike Gyra, Sigrid Johannes, Manfred Wilhelm and Klaus Cussler
Acute Toxic Class Methods: Alternatives to LD/LC50 Tests
Wolfgang Diener and Eva Schlede
Embryonic Stem Cells In Vitro -- Prospects for Cell and Developmental Biology, Embryotoxicology and Cell Therapy
Kaomei Guan, Michael M. Schmidt, Qing Ding, Hong Chang and Anna M. Wobus
SHORT COMMUNICATIONS
Genetic Algorithms in 3D-QSAR: The Use of Multiple Ligand Orientations for Improved Predictions of Toxicity
Angelo Vedani, Daniel R. McMasters und Max Dobler
New Applications of the Human Whole Blood Pyrogen Assay (PyroCheck)
Stefan Fennrich, Albrecht Wendel and Thomas Hartung
Validation of In Vitro Tests for Skin Corrosivity
Julia H. Fentem
PROCEEDINGS OF ZEBET'S 10 YEAR ANNIVERSARY
Welcome
Andrea Fischer
National Co-operation
ZEBET: Institutionalised Co-operation between Animal Welfare, Industry and the Government
Brigitte Rusche
ZEBET and the Cosmetic Industry: a Decade of National and International Co-operations
Wolfgang J. W. Pape
International Co-operation
Symposium "Implementation of the 3R targets in the EU, in Science and Industry" (abstract only)
Wolf Frühauf
Validation and Regulatory Acceptance of Alternative Test Methods and International Co-operation
Neil L. Wilcox
Improving International Co-operation between National Organisations Promoting the Three Rs
Jan van der Valk and Arthur van Iersel
Improving International Co-operation between Organisations Promoting the Three Rs (abstract only)
Bob Combes
Co-operation between ZEBET and Charles University Faculty of Medicine
Miroslav Cervinka and Zuzana Cervinková
Regulatory Toxicology: Validation of In Vitro Tests and Test Strategies at the BgVV
Alternatives to the Draize Eye Test: Current Status of Validation and Acceptance in Europe (abstract only)
Horst Spielmann
Validation of In Vitro Phototoxicity Tests: Current Status and Future Perspectives (abstract only)
Manfred Liebsch
Embryotoxicity Screening Using ES Cells In Vitro: Correlation to In Vivo (abstract only)
Gabriele Scholz, Ingeborg Pohl, Elke Genschow, Martina Klemm and Horst Spielmann
Introduction of SAR Considerations and Specific In Vitro Tests into Skin and Eye Irritation/Corrosion Testing Strategies (abstract only)
Ingrid Gerner and Stephan Zinke
Institutions Funding Research According to the 3Rs: The Funding of Research on the Three Rs in the EU (abstract only)
Michael Balls
Funding for Activities Involving the Three R's in the United States
Rodger D. Curren
Institutions Funding Research According to the 3Rs in Germany
Paul-Friedrich Langenbruch
Research Funded by ZEBET in the Past 10 Years
The Establishment of the V79 Cell Battery and its Application in Toxicology and Pharmacology (abstract only)
Johannes Doehmer, N. Krebsfänger, W. Schober, A. Luch, and J. T. M. Buters
Egg Yolk Antibodies (IgY) as an Alternative to Polyclonal Mammalian Antibodies. The History of the Achievements of a Joint Project on IgY-Technology in Germany (abstract only)
Rüdiger Schade
Bioartificial Thin Section Liver Analogues Maintain Cytochrome P450 Induction Properties and Can be Cryopreserved (abstract only)
Augustinus Bader, Angelika Langsch, Ute Weingartz, Karin Burgwitz and Axel Haverich
The Isolated Perfused Bovine Udder as a Model of Transdermal Penetration and Absorption of Drugs (abstract only)
Manfred Kietzmann
Support Provided by Information Services
The ZEBET Database and Information Service
Barbara Grune, Antje Dörendahl, Susanne Skolik and Horst Spielmann
The ECVAM Scientific Information Service (SIS)
Annett Janusch-Roi and Michael Balls
The Animal Welfare Information Center -- A Brief Overview
Jean Larson
Experience in Sweden
Ulrika Hansson
Empowering the End User - the UK Perspective
Krys Bottrill
Selected Posters
Organotypic Hippocampal Slice Cultures as In Vitro Model for Testing Neuroprotective Drugs in Preclinical Stroke Research (abstract only)
Jörg Breder, Clemens F. Sabelhaus, Akila Benabdallah, Ulrich H. Schrsder and Klaus G. Reymann
In Vitro Adhesion and Invasion of Epithelial Cell Lines by Salmonella Strains of Different Epidemiological Origin (abstract only)
Ute Dinjus and Ingrid Hänel
Cytotoxicity and Membrane Toxicity of Usual Surfactants (abstract only)
Antje Jelinek, Sylvia Grabs, Simone Kühn, and Hans-Peter Klöcking
New Molecular Bioassays In Vitro for the Estimation of the Teratogenic Potency of Valproic Acid-Derivatives (abstract only)
Alfonso Lampen, Martin Göttlicher, Ursula Ellerbeck and Heinz Nau
A Tiered In Vitro/In Vivo Testing Strategy to Classify Severely Eye Irritating Chemicals Using Two Alternatives to the Draize Eye Test, the HET-CAM Test and the 3T3 NRU Cytotoxicity (abstract only)
Horst Spielmann, Manfred Liebsch, S. Kalweit, F. Moldenhauer, T. Wirnsberger, H. G. Holzhütter, B. Schneider, S. Glaser, I. Gerner, Wolfgang I. W. Pape, R. Kreiling, K. Krauser, H. G. Miltenburger, W. Steiling, N. P. Luepke, Peter Günzel, N. Müller, H. Kreuzer, P. Mürmann, J. Spengler, E. Bertram-Neis, B. Siegemund, and F. J. Wiebel
Hepatocyte Bioreactors for In Vitro Studies on Drug Metabolism in the Pharmaceutical Industry as an Alternative to Animal Testing (abstract only)
Katrin Zeilinger, Stefan Auth, Alexander Grebe, Lei Mao, Martin Petrik, Gudrun Holland, Kurt Appel, Andreas NYssler, Peter Neuhaus, and Jörg Gerlach