ALTEX :: Alternatives to Animal Experiments

2001, VOLUME 1

CONTENTS :: MAIN ARTICLES

Innovative Cell Culture Methods in Drug Development
Claudia Schleger, Niels Krebsfaenger, Arno Kalkuhl, Rainer Bader and Thomas Singer

Modern Drug Development by Molecular and Cellbiological Methods
Johannes Döhmer

Recent Developments on the European Ban on Animal Experiments for Cosmetics
Irmela W. Ruhdel

Development of Alternative Methods by the EDQM and the Biological Standardisation Programme
Karl-Heinz Buchheit

"Replacement Methods to Animal Testing" as the Incentive Topic of the German Ministry of Education and Research (BMBF). Selected Results to Biological Drugs
Wilfried Diekmann and Manfred Hansper

One Century of Erysipelas Prophylaxis: Significance and Reduction of Animal Experiments
Klaus Cussler and Elisabeth Balks

Development of in vitro Methods for the Potency Testing of Clostridial Vaccines
Erika Borrmann, Frank Schulze and Roland Diller

Clinical Endpoints During Rabies Vaccine Control Tests
Joachim Hartinger, Tamara Folz and Klaus Cussler

A New Application for the Human Whole Blood Test: Development of an Assay to Assess the Health Risk of Air-Borne Microbial Contaminations
Stefan Fennrich, Bert Zucker and Thomas Hartung

Influence of the Preservative Thiomersal on the Interleukin-1-Beta Release of Human Peripheral Blood Cells
Matthias Fischer, Brigitte Keller-Stanislawski, Susanne Schober-Bendixen, Rudolf Schosser, Katrin Hacke, Thomas Hartung and Thomas Montag

Development of a Novel Influenza Vaccine Derived from a Continuous Cell Line
Otfried Kistner, Noel Barrett, Wolfgang Mundt, Manfred Reiter, Susanne Schober-Bendixen, Gerald Eder and Friedrich Dorner

Mediator Release Assay of Rat Basophil Leukemia Cells as Alternative for Passive Cutaneous Anaphylaxis (PCA)
Susanne Kaul und Andreas Hoffmann

In vitro Intestinal and Alveolar Epithelium Cultures in Drug Research
Claus-Michael Lehr

Good Cell Culture Practice (GCCP) -- an Initiative for Standardisation and Quality Assurance of in vitro Studies. The Establishment of an ECVAM Task Force on GCCP
Thomas Hartung, Gerhard Gstraunthaler, Sandra Coecke, David Lewis, Olivier Blanck and Michael Balls

The Importance of Standardised Cell Culture Methods for the Routine Toxicology in Pharmaceutical Companies
Gabriele Schmuck

In vitro Permeability Studies as Substitute for in vivo Studies -- Which Requirements Have to be Met?
Dr. Eleonore Haltner, Dr. Stefan Schmitz, Christiane Gindorf and Dr. Jörg Ruoff

CALL FOR PAPERS

Establishment and Characterisation of an Immortalised Human Sebaceous Gland Cell Line (SZ95)
Holger Seltmann, Heidemarie Neitzel, Constantin E. Orfanos and Christos C. Zouboulis

Comparative Evaluation of in vitro Test Systems for Pulmonary Drug Delivery Based on Airway Epithelial Cell Lines and Human Alveolar Epithelial Cells (HAEC) in Primary Culture
Carsten Ehrhardt, Sabine Fuchs, Ulrich Friedrich Schäfer and Claus-Michael Lehr

The Use of Reconstructed Skin Equivalents in Permeation Studies with Pharmaceutical Dosage Forms
Nadia Zghoul, Heike Wagner, Claus-Michael Lehr and Ulrich Schäfer

Regulation of Components of the Fibrinolytic System in Human Adult Cardiac Myocytes (HACM)
Karin Macfelda, Christoph Kaun, Gerlinde Zorn, Ulrich Oberndorfer, Philipp Holzmann, Barbara Kapeller, Margit Vögele-Kadletz, Udo M. Losert, Gerald Maurer, Kurt Huber and Johann Wojta

Three-Dimensional Culture of Human Articular Chondrocytes in Rotating-Wall Vessels
Stefan Marlovits, Vilmos Vécsei, Michaela Truppe, Markus Dezfulian, and Brigitte Tichy

Dedifferentiation of Aged Human Articular Chondrocytes in Monolayer Culture
Michaela Truppe, Stefan Marlovits, Brigitte Tichy, and Vilmos Vécsei

Studies on CCK-Processing of Primary Neuronal Cell Cultures Obtained from Fertilised Eggs Instead of Rat Foetuses
Rüdiger Schade, Mirko Sasse, Peter Henklein and Andreas Hlinak

Replacement of Fetal Calf Serum by an Egg Yolk Factor with CCK/Gastrin-like Immunoreactivity in Cell Culture
Mirko Sasse, Thomas Lengwinat, Peter Henklein, Andreas Hlinak and Rüdiger Schade

Ex vivo Model to Investigate the Effect of 17β-Estradiol and of the Phytoestrogens Genistein and Daidzein on Post Injury Neointima Formation in Non-Toxic Concentrations
Gerald Finking, Christina Lenz and Hartmut Hanke

A New High Resolution ECG Technique for Cardiac Conduction and Refractoriness Measured with in vitro Perfused Mice Hearts
Andreas Lueger, Gerhard Stark, Marianne Brodmann and Helmut A. Tritthart

In vitro Measurement of Cancer Tissue Invasion into Healthy Tissue as a Replacement Method for Animal Experiments
Helmut A. Tritthart, Trevor DeVaney, Manfred Hartbauer and Helmut Ahammer

Biomaterials in vitro: Monitoring Cell Lines from Primary Cultures using Multilocus-DNA-Fingerprinting
Erwin Falkner, Wolfgang Ficke, Barbara Kapeller, Heidrun Eberl, Karin Macfelda, Udo Losert