ALTEX :: Alternatives to Animal Experiments

2001, VOLUME 2

CONTENTS :: MAIN ARTICLES

The Suitability of Hepatocyte Culture Models to Study Various Aspects of Drug Metabolism
Andreas K. Nussler, Aiguo Wang, Peter Neuhaus, Judith Fischer, Jing Yuan, Liegang Liu, Katrin Zeilinger, Jorg Gerlach, Peter J. Arnold and Wolfgang Albrecht

Reconstructed Skin Equivalents for Assessing Percutaneous Drug Absorption from Pharmaceutical Formulations
Nadia Zghoul, Roland Fuchs, Claus-Michael Lehr and Ulrich F. Schaefer

Replacement of the Pyrogen-Test as Batch Control Test for the Biological Substances Aprotinin and Urokinase
Karl-Heinz Diehl

Internet Laboratory for Predicting Harmful Effects Triggered by Drugs and Chemicals. Concept and Call for Co-Operation
Angelo Vedani and Max Dobler

Report on the ICCVAM Workshop on in vitro Methods for Assessing Acute Systemic Toxicity
Elke Genschow, Manfred Liebsch, Willi Halle und Horst Spielmann

In vitro Methods for Phototoxicity and Photocarcinogenicity Testing of Drugs
Lutz Müller, Susanne Brendler-Schwaab, Peter Kasper and Birgit Kersten

Prediction of Embryotoxic Effects of Valproic Acid-Derivatives with Molecular in vitro Methods
Alfonso Lampen, Martin Göttlicher and Heinz Nau

Permanent Embryonic Mouse Germ Cell-Lines, an in vitro Alternative to in vivo Germ Cell Mutagenicity Tests
Martina Klemm, Elke Genschow, Inge Pohl, Christa Barrabas, Manfred Liebsch and Horst Spielmann

POSTERS

Inter-Species Variations in Ochratoxin A Protein Binding and Uptake
Daniel R. Dietrich, Evelyn OŽBrien, Alexandra Heussner, Michael Stock, Klaus Hochberg and Billy W. Day

A New Transgenic Embryonic Stem Cell Clone with Endodermal GFP Expression as Part of a Reporter Gene Test Battery for Embryotoxicity
Martin Paparella and Susanne Bremer

Comparison of Cytotoxic Effects of Ochratoxin A and B on Human, Rat and Porcine Renal Cells
Alexandra Heussner, Michael Stack, Klaus Hochberg and Daniel R. Dietrich

High Correspondence of Botulinum Neurotoxin C1 (BoNtC1) Detection by Mouse Bioassay and Corresponding Gene Detection by PCR After Enrichment with Cooked Meat Medium: An Alternative for the Mouse Bioassay Investigating the Presence of Viable BoNtC1 Toxigenic Clostridia
Thomas Christian Zechmeister, Alexander Konrad Theodor Kirschner, Alexander Eiler, Sylvia Kölbl, Alois Herzig, Friedrich Pittner, Renate Rosengarten, Robert Ludwig Mach and Andreas Herbert Farnleitner

Antiproliferative and Cell Cycle Specific Effects of Ochratoxin A in LLCPK-1, NRK-52E and Porcine Primary Proximal Kidney Cells
Stefanie B. Dreger, Evelyn O'Brien and Daniel R. Dietrich

Permanent Female and Male EG-Cell-Lines of Balb/CJ Mice--an Alternative Concept for Reproductive Toxicity Testing?
Martina Klemm, Elke Genschow, Manfred Liebsch and Horst Spielmann