ATLA::Alternatives to Laboratory Animals

Volume 23, Number 5

Chimpanzees biomedical experiments: a question of efficacy.

ATLA 23, 584-591, September/October 1995

Roger Fouts

Chimpanzee and Human Communication Institute, Central Washington University, Ellensburg, Washington 98926, USA

SUMMARY

The efficacy of biomedical research on chimpanzees is addressed from an empirical point of view. The confounding effects of "standard housing" on experiments are examined, with regard to deleterious effects on the neurophysiological makeup of the subjects and thus the effects on the results of any research examining neurological or immunological factors. Also, specious symptom similarity can cause one to assume a common aetiology, which is often unwarranted. The assumption of common reactions from different species violates sound scientific procedures. The high probability of Type 1 errors in the chimpanzee AIDS model is discussed. Also, unjustified generalization across species is discussed. Finally, the rational and ethical problems surrounding the use of chimpanzees in biomedical research are discussed.

Keywords: aetiology, AIDS, chimpanzees, biomedical research, efficacy, empiracal, experimental confounds, falsegeneralisations, HIV, individual differences, standard housing, Type 1 errors