ATLA :: Alternatives to Laboratory Animals

Volume 23, Number 6
November/December 1995

CONTENTS

EDITORIAL

Reduction, refinement and replacement: the end of an era, new beginnings, and new challenges

NEWS AND VIEWS

ECVAM NEWS AND VIEWS

LETTER FROM CAAT

PREFATORY NOTE

ARTICLES

On keeping your eyes on the prize: Dorothy Hegarty and acceptance of the concept of replacement of laboratory animal procedures in research, education and testing.
M. Balls

The progress of humane experimental techniques since 1959: a personal view.
R.L. Burch

Computer simulation in drug research.
W.G. Richards

Cytotoxicity of biomaterials -- basic mechanisms and in vitro test methods: a review.
T. Groth, P. Falck & R-R. Miethke

Determination of critical cellular neurotoxic concentrations in human neuroblastoma (SH-SY5Y) cell cultures.
A. Forsby, F. Pilli, V. Bianchi & E. Walum

Advances in refinement in animal experimentation over the past 25 years.
D.B. Morton

Alternatives in Canada.
G. Griffin

Benefits, necessity and justification in animal research.
M. Jennings & S. Silcock

ECVAM Workshop Reports

The Three Rs: the way forward.
M. Balls, A.M. Goldberg, J.H. Fentem, C.L. Broadhead, R.L. Burch, M.F.W. Festing, J.M. Frazier, C.F.M. Hendriksen, M. Jennings, M.D.O. van der Kamp, D.B. Morton, A.N. Rowan, C. Russell, W.M.S. Russell, H. Spielmann, M.L. Stephens, W.S. Stokes, D.W. Straughan, J.D. Yager, J. Zurlo & B.F.M. van Zutphen

Screening chemicals for reproductive toxicity: the current alternatives.
N.A. Brown, H. Spielmann, R. Bechter, O.P. Flint, S.J. Freeman, R.J. Jelínek, E. Koch, H. Nau, D.R. Newall, A.K. Palmer, J-Y. Renault, M.F. Repetto, R. Vogel & R. Wiger

COMMENT

The validation of alternative test methods.
M. Balls & W. Karcher

AROUND THE WORLD

What is SCAW?
V. de Liedekerke

Abstracts of the main articles published in ALTEX Volume 12 1995

CONFERENCE REPORTS

CONFERENCE DIARY

BOOK REVIEWS

A guide to the laboratory culture of human skin cells / Advances in drug metabolism in man / Alternatives to animal experimentation

SELECTED TITLES

SELECTED TITLES INDEX

AUTHOR INDEX

SUBJECT INDEX