ATLA :: Alternatives to Laboratory Animals

Volume 24, Number 1
January/February 1996

CONTENTS

EDITORIAL

Current progress in the validation of alternative test methods

NEWS AND VIEWS

LETTER FROM CAAT

ARTICLES

Intestinal motility: a computer simulation of the effects of drugs on colonic peristalsis, for teaching undergraduate pharmacology students.
D. Dewhurst, H. Leathard & R. Ullyott

The development of corneal opacity, increased hydration and increased thickness in isolated porcine corneas in response to timolol maleate solutions containing various preservatives.
H. Igarashi, C. Sato, Y. Chiba, K. Ogawa & M. Kojima

A comparison of hepatic enzyme activities and their modulation by dexamethazone in freshly isolated and cultured hepatocytes and in the differentiated hepatoma cell lines, 2sFou.
M.J. Garle & J.R. Fry

Toxicity of bread wheat lines lacking prolamins encoded by the Gli-B1/Bli-B5/Glu-B3 and Gli-D1/Glu-D3 loci in coeliac disease as determined by their agglutinating activity.
M. De Vincenzi, M.R. Dessí, R. Luchetti, N. Pogna, R. Redaelli & G. Galterio

Application of statistical classification methods to the evaluation of in vitro tests.
S. Galser

Determination of phosphofructokinase and enolase activities in cultured mouse neuroblastoma cells: application to the in vitro detection of neurotoxic effects.
M.I. Andres, G. Repetto, P. Sanz & M. Repetto

The development and interlaboratory validation of a quantitative antibody capture ELISA for the measurement of specific guinea-pig IgG1: an alternative to the passive cutaneous anaphylaxis assay.
L.S. Babcock, T.T. Kawabata, V.S. Moore, C.M. Condo & A. Prentø

ECVAM Workshop Report

Methods for assessing percutaneous absorption.
D. Howes, R. Guy, J. Hadgraft, J. Heylings, U. Hoeck, F. Kemper, H. Maibach, J-P. Marty, H. Merk, J. Parra, D. Rekkas, I. Rondelli, H. Schaefer, U. Täuber & N. Verbiese

COMMENT

Alternative methods and cosmetic testing
M. Balls

The production of monoclonal antibodies: are animals still needed?
C. Hendriksen, J. Rozing, M. van der Kamp & W. de Leeuw

Regulatory toxicity testing and the Animals (Scientific Procedures) Act 1986

CONFERENCE REPORT

CONFERENCE DIARY

BOOK REVIEWS

Animal genetic engineering: of pigs, oncomice and men / Photobiology / Laboratory animals: an introduction for experimenters / Planning and managing dissection laboratories / Finding out... about animals in medicines research / Experimental toxicology: the basic issues

SELECTED TITLES