ATLA :: Alternatives to Laboratory Animals

Volume 29, Number 3
May / June 2001

CONTENTS

EDITORIAL

Scientific progress and animal welfare: conflicting goals or complementary opportunities?

NEWS AND VIEWS

ARTICLES

The Eighteenth Workshop of the Scandinavian Society for Cell Toxicology

Obituary:
Björn Ekwall MD PhD, 1940-2000: a pioneer in the field of in vitro toxicology
E. Walum

Cytotoxicity of the MEIC reference chemicals in antioxidant-enriched rat hepatoma-derived Fa32 cells.
P.J. Dierickx, C. Smit & E.M. Scheers

The use of cultured hepatocytes to investigate the metabolism of drugs and mechanisms of drug hepatotoxicity.
M.J. Gómez-Lechón, X. Ponsoda, R. Bort & J.V. Castell

The DRAG test: an assay for detection of genotoxic damage.
T. Helleday, F. Johansson & D. Jenssen

Caspase-3 activity and carbonyl cyanide m-chlorophenylhydrazone-induced apoptosis in HL-60 cells.
P. Mlejnek

Metabolic activity in primary cultures of fish hepatocytes.
H. Segner & J-P. Cravedi

Study of the environmental hazard caused by the oil shale industry solid waste.
L. Põlumaa, A. Maloveryan, M. Trapido, H. Sillak & A. Kahru

Cytotoxicity testing of wound-dressing materials.
H. Sahlin & H. Nygren

Biochemical responses in aquatic plants as markers of environmental contamination.
P Lindström-Seppä, K. Urban, U. Honkalampi-Hämäläinen & S. Roy

Extended Abstracts:

The formation of free radicals in human granulocytes and cerebellar granule cells.
F. Fonnum, O. Myhre, Ø.A. Voie, J.M. Andersen & A. Dreiem

Molecular profiling and prediction of toxicity.
I. Schuppe-Koistinen

Multivariate modelling of polychlorinated biphenyl-induced CYP1A activity in the MH1C1 rat hepatoma cell line.
M. Öberg, P.L. Andersson, N. Johansson, M. Tysklind & H. Hâkansson

Long-term in vitro toxicity of 27 MEIC chemicals on Hep G2 cells.
E.M. Scheers, B. Ekwall & P.J. Dierickx

Preliminary results of the ECVAM validation study on three in vitro embryotoxicity tests.
H. Spielmann, E. Genschow, G. Scholz, N.A. Brown, A.H. Piersma, M. Brady, N. Clemann, H. Huuskonen, F. Paillard, S. Bremer & K. Becker

Integration of in vitro approaches to predict drug metabolism and interaction in man: an EU validation project.
M. Ingelman-Sundberg

Test validation: from animal data comparison to prospective evaluation.
E. Walum

Protein precipitation in vitro as a measure of chemical-induced cytotoxicity: an EDIT sub-programme.
A. Novillo, B. Ekwall & A. Castaño

Uniform expression of alcohol dehydrogenase 3 in epithelia regenerated with cultured normal, immortalised and malignant human oral keratinocytes.
J.J. Hedberg, A. Hansson, J.A. Nilsson, J-0. H&omul;ög & R.C. Grafström

Pyruvate-induced long-term maintenance of glutathione S-transferase in rat hepatocyte cultures.
T. Vanhaecke, A. Foriers, A. Geerts, E.A. Shephard, A. Vercruysse & V. Rogiers

A compartment model to calculate time-dependent concentration profiles of topically applied chemical compounds in the anterior compartments of the rabbit eye.
H. Pospisil & H-G. Holzhütter

COMMENT

A major initiative from the European pharmaceutical industry and ECVAM.
D.W. Straughan

CONFERENCE DIARY

BOOK REVIEWS

Chicken egg yolk antibodies, production and application, IgY-technology / Animal experimentation: a guide to the issues

SELECTED TITLES