Print this page / Imprima esta página
ATLA :: Alternatives to Laboratory Animals
Volume 30, Supplement 2
December 2002
CONTENTS
PREFACE
INTRODUCTION
The importance of ECVAM
K. van Leeuwen
The establishment of ECVAM and its progress since 1993
M. Balls
VALIDATION
The principles of validation and the ECVAM validation process
A.P. Worth & M. Balls
The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM): a review of the ICCVAM test method evaluation process and current international collaborations with the European Centre for the Validation of Alternative Methods (ECVAM)
W.S. Stokes, L.M. Schechtman & R.N. Hill
Validation successes: chemicals
H. Spielmann & M. Liebsch
ECVAM's role in the implementation of the Three Rs concept in the field of biologicals
C. Hendriksen, K. Cussler & M. Halder
Alternative Methods: Examples of ECVAM's External Collaborations
Comparison and validation of novel pyrogen tests based on the human fever reaction
T. Hartung & Members of the Human(e) Pyrogen Test Study Group
Transepithelial resistance and inulin permeability as endpoints in in vitro nephrotoxicity testing
T. Duff, S. Carter, G. Feldman, G. McEwan, W. Pfaller, P. Rhodes, M. Ryan & G. Hawksworth
ECVAM's activities in validating alternative tests for skin corrosion and irritation
J.H. Fentem & P.A. Botham
Ocular safety: a silent (in vitro) success story
R.D. Curren & J.W. Harbell
In vitro tests for haematotoxicity- prediction of drug-induced myelosuppression by the CFU-GM assay
A. Pessina, B. Albella, M. Bayo, J. Bueren, P. Brantom, S. Casati, C. Croera, R. Parchment, D. Parent-Massin, G. Schoeters, Y. Sibiri, R. Van Den Heuvel & L. Gribaldo
The current status and future applicability of quantitative structure-activity relationships (QSARs) in predicting toxicity
M.T.D. Cronin
The necessity of biokinetic information in the interpretation of in vitro toxicity data
B.J. Blaauboer
Selected biostatistical aspects of the validation of in vitro toxicological assays
L.A. Hothorn
Alternative Methods: Examples Of ECVAM's Internal Activities
Barriers, nephrotoxicology and chronic testing in vitro
P. Prieto
Development of a testing strategy for detecting embryotoxic hazards of chemicals in vitro by using embryonic stem cell models
S. Bremer, C. Pellizzer, S. Adler, M. Paparella & J. de Lange
Haematotoxicology: scientific basis and regulatory aspects
L. Gribaldo
Metabolism and neurotoxicity: the significance of genetically engineered cell lines and new three-dimensional cell cultures
S. Coecke, C. Eskes, J. Gartion, E. van Vliet, A. Kinsner, A. Bogni, L. Raimondo, N. Parissis & I. Langezaal
ECVAM's research and validation activities in the fields of topical toxicity and human studies
V. Zuang
ECVAM's activities on biologicals
M. Halder, M. Balls, C. Hendriksen & K. Cussler
Genomics: an in vitro toxicology point of view
R. Corvi
ECVAM's activities on computer modelling and integrated testing
A.P. Worth
Databases and Communications
The ECVAM Scientific Information Service (SIS)
A.J. Roi
Information: needs for the future
K. Bottrill
Dialogue and Collaboration
ECVAM: desperately needed or superfluous? An animal welfare perspective
R. Kolar
ECVAM's collaboration with academia
R. Clothier
ECVAM, ECETOC and the EU chemicals policy
P.A. Botham
Dialogue and collaboration with ECVAM: the view of the EFPIA
B. Garthoff
ecopa: a powerful concept in the way forward for alternative methods
V. Rogiers
ECVAM'S activities in the EU candidate countries
D. Gladowski & M. Halder
Dialogue and collaboration: a personal view on laboratory animal welfare developments in general, and on ECVAM's first decade in particular
H.B.W.M. Koëter
The EC White Paper on a Strategy for a Future Chemicals Policy
J. Vogelgesang
The Seventh Amendment to the Cosmetics Directive: what does DG Enterprise want from ECVAM?
R. Schumann
Future Activities
Directive 86/609/EEC on the protection of animals used for experimental and other scientific purposes
S. Louhimies
ECVAM and pharmaceuticals
P. Vanparys
Future activities: ECVAM and the quality control of biologicals
K. Cussler, M. Halder & C. Hendriksen
ECVAM-ICCVAM: prospects for future collaboration
L.M. Schechtman & W.S. Stokes
Closing Activities
The future of ECVAM: a personal perspective
M. Balls
ECVAM Status Seminar 2002: closing remarks
D.G. Clark