ATLA :: Alternatives to Laboratory Animals

Volume 31, Number 3
May / June 2003

CONTENTS

EDITORIAL
How much flexibility is possible when validating new in vivo and in vitro toxicity test methods?

NEWS AND VIEWS

ECVAM NEWS AND VIEWS

ARTICLES

The Twentieth Workshop of the Scandinavian Society for Cell Toxicology

New achievements in human cell toxicology: the 20th Annual Workshop on in vitro Toxicology.
A. Kolman

The prediction of human acute systemic toxicity by the EDIT/MEIC in vitro test battery: the importance of protein binding and of partitioning into lipids.
C. Clemedson, PJ. Dierickx & M. Sjöström

Human hepatic cell cultures: in vitro and in vivo drug metabolism.
M.J. Gómez-Lechón, T. Donato, X. Ponsoda & J.V. Castell

Bridging the gap between in vitro and in vivo toxicology testing.
M. Ehrich

Refining in vitro neurotoxicity testing -- the development of blood-brain barrier models.
H. Tähti, H. Nevala & T. Toimela

Biokinetic and toxicodynamic modelling and its role in toxicological research and risk assessment.
B. J. Blaauboer

Use of the PFGE. assay for studies of DNA breakage induced by toxic chemicals.
E. Markova, C. Clemedson & A. Kolman

Buying or making, what's it to be? The choice between acquiring or generating genetically modified animals or embryos in the light of the Three Rs.
N. Cohen & T. de Cock Buning

Sensory nerves, neurogenic inflammation and pain: missing components of alternative irritation strategies? A review and a potential strategy.
M. J. Garle & J. R. Fry

ECVAM WORKSHOP REPORT

The use of fish cells in ecotoxicology.
A. Castaño, N. Bols, T. Braunbeck, P. Dierickx, M. Halder, B. Isomaa, K. Kawahara, L.E.J. Lee, C. Mothersill, P. Pärt, G. Repetto, J. R. Sintes, H. Rufli, R. Smith, C. Wood & H. Segner

COMMENTS

A critical assessment of the European Commission's proposals for the risk assessment and registration of chemical substances in the European Union
R. Combes, J. Dandrea & M. Balls

CONFERENCE DIARY

SELECTED TITLES