ATLA :: Alternatives to Laboratory Animals

Volume 31, Supplement 1
June 2003

CONTENTS

INTRODUCTION
M. Balls

ARTICLES

Biostatistical methods for the validation of alternative methods for in vitro toxicity testing.
L. Edler & C. Ittrich

Statistics of interlaboratory in vitro toxicological studies.
L.A. Hothorn

The role of control groups in mutagenicity studies: matching biological and statistical relevance.
D. Hauschke, L.A. Hothorn & J. Schäfer

Two-stage testing of safety: a statistical view.
F. Bretz & L.A. Hothorn

Statistical analysis of monotone or non-monotone dose-response data from in vitro toxicological assays.
F. Bretz & L.A. Hothorn

Dose-response and thresholds in mutagenicity studies: a statistical testing approach.
L.A. Hothorn & F. Bretz