ATLA::Alternatives to Laboratory Animals

Volume 31, Supplement 1

Statistical analysis of monotone or non-monotone dose-response data from in vitro toxicological assays.

Frank Bretz and Ludwig A. Hothorn

Bioinformatics Unit, University of Hannover, 30419 Hannover, Germany

SUMMARY

Various tests on trend in toxicological studies are reviewed, and the advantages and the disadvantages involved with such procedures are discussed. New tests are introduced to overcome difficulties common to many current procedures, such as downturns at higher doses, and missing numerical availability.

Keywords: contrast test, dose-response analysis, in vitro toxicological assay, non-monotone, trend test