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Adjuvants in Laboratory Animals
Evaluation of immunostimulating properties and side effects of Freund's complete adjuvant and alternative adjuvants in immunization procedures
Printed by: Ponsen & Looijen BV, Wageningen
Authored by: Dr. P.P.A. Marlies Leenaars
The studies presented in this thesis were perfommed at the Division Immunological and Infectious Diseases (I&I), TNO Prevention and Health (TNO-PG), Leiden, the Netherlands, and the Central Animal Laboratory, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands. The research was financially supported by the RIVM-lnstitute's Centre for Alternatives to Animal Testing, Bilthoven, the Division I&I, TNO-PG, Leiden and the Department of Immunology, Erasmus University, Rotterdam.
The printing of this thesis was financially supported by:
RlVM-lnstitute's Centre for Altematives to Animal Testing, Bilthoven
TNO-PG, Leiden
Erasmus University, Rotterdam
Contents
| List of abbreviations | |
| Chapter 1 | Introduction |
| Chapter 2 | Antigens and antigen presentation Immunology Methods Manual, 1997, pp. 989-1013 |
| Chapter 3 | Evaluation of several adjuvantsas alternatives to the use of Freund's adjuvant in rabbits Vet. Immunol. Immunopathol., 1994, 40: 225-241 |
| Chapter 4 | Comparison of several types of adjuvants for immune potentiating properties and side effects in mice Vet Immunol. Immunopathol., 1995, 48: 123-138 |
| Chapter 5 | Assessment of side effects induced by injection of different adjuvanVantigen combinations in rabbits and mice submitted |
| Chapter 6 | Immune responses and side effects of five different oil based adjuvants in mice Vet Immunol. Immunopathol., in press |
| Chapter 7 | Model to test efficacy of immunization procedures by early cytokine production in mice Animal Altematives Welfare and Ethics, 1997, in press |
| Chapter 8 | Increased adjuvant efficacy in stimulation of antibody responses after macrophage elimination in viva Immunology, 1997, 90: 337-343 |
| Chapter 9 | A rapid and simple method to localize oil based adjuvants in viva J. Immunol Methods, in press |
| Chapter 10 | General discussion
References |