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Alternative Methods in Toxicology

Volume 2 - Acute Toxicity Testing: Alternative Approaches

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers


Table of Contents

Part One: Acute Toxicity Testing

  1. Acute Toxicity Testing, Purpose
    Gerhard Zbinden
  2. Acute Toxicity Testing, Practice
    Thomas E. Hickey
  3. Regulatory Uses of Acute Toxicity Data
    Paul H. LaFlamme
  4. The FRAME Research Programme on In Vitro Cytotoxicology
    Michael Balls and James W. Bridges
  5. Hazard Identification with Small Numbers of Animals: Implications for Risk Assessment
    Victor G. Laites and Ronald W. Wood

Part Two: Poster Presentations

  1. In Vitro Cytotoxicity Assays as Potential Alternatives to the Draize Ocular Irritancy Test
    C. Shopsis, E. Borenfreund, J. Walberg, and D. Star
  2. The Toxicity of Sixteen Metallic Compounds in Chinese Hamster Ovary Cells: A Comparison with Mice and Drosophila
    A.W. Hsie, R.L. Schenley, E.-L. Tan, W.E. Perdue, M.W. Williams, T.L. Hayden, and J.E. Turner
  3. Development of an In Vitro Test for Cytotoxicity in Vaginal Tissue: Effect of Ethanol on Prostanoid Release
    N.H. Dubin, M.C. DiBlasi, C.L. Thomas, and M.C. Wolff
  4. An Assessment of the Importance of Number of Dosage Levels, Number of Animals per Dosage Level, Sex and Method of LD50, and Slope Calculation in Acute Toxicity Studies
    L.R. DePass, R.C. Myers, E.V. Weaver, and C.S. Weil
  5. An In Vitro Novel Technique for Screening Antifote Potentiality of Drugs
    K.S. Swami and K.S. Jagannatha Rao
  6. Methodology Updating of Acute Toxicity Testing
    R. Bass, H.P. Gelbke, C. Gloxhuber, H. Greim, P. Gunzel, D. Henscler, A. Hildebrandt, D. Kayser, J. Konig, D. Lorke, D. Neubert, E. Schultz, D. Schuppan, G. Zbinden

Poster Abstracts

  1. Validation of a Structure-Activity Model of Rat Oral LD50
    T. Lander, K. Enslein, P. Craig, and M. Tomb
  2. An Up-and-Down Procedure for Acute Toxicity Testing
    Robert D. Bruce

Part Three: Workshops

  1. Charge to Workshops: Definitions and Goals
    Alan Goldberg
  2. Opening Statement of Workshops:
    • Statistical Considerations and Protocols Using Small Numbers of Animals. Introductory Remarks
      Gerard Zbinden
    • Species and Host Factors in Safety Evaluation
      Gareth M. Green
    • The Preselection or Establishment of a Hierarchy of Chemicals in Safety Evaluation
      Warren Muir
    • Protocol Development and the Scientific and Clinical Uses of Acute Toxicity Data
      David A. Blake
  3. Summaries of Workshops:
    • Statistical Considerations and Protocols Using Small Numbers of Animals. Introductory Remarks
      Charles Rohde
    • Species and Host Factors in Safety Evaluation
      John A. Moore
    • The Preselection or Establishment of a Hierarchy of Chemicals in Safety Evaluation
      Robert Squire
    • Protocol Development and the Scientific and Clinical Uses of Acute Toxicity Data
      Paul Kotin

Part Four: Regulatory Implications

  1. Summary: Regulatory Implications
    W. Gary Flamm

New ALTEX: 3/2017
ALTEX 3/2017 cover

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MeetingS

 
FRAME Training School in Experimental Design and Statistical Analysis
May 31-June 2, 2017
Saskatoon, Canada

Advances in Cell and Tissue Culture 2017
May 22-24, 2017
Manchester, UK

CAAT Academy
In Vitro Skin and Eye Models Hands-on Training
June 1-2 2017
Brussels, Belgium

CAAT Academy
Tools for Read-Across
June 15-16, 2017
Helsinki, Finland

ecopa SSCT Workshop 2017
June 14-16, 2017
Helsinki, Finland
Thomas Hartung will deliver a keynote address

CAAT Academy
Updates on Hepatotoxicity AOP Landscape and on the ADME Field - Season 2
June 22-23, 2017
Rennes, France

9th Euro-Global Summit on Toxicology and Applied Pharmacology
June 22-24, 2017
Paris, France
Email for Details

6th Annual Meeting of the American Society for Cellular and Computational Toxicology (ASCCT)
September 21-22
College Park, MD

SAVE THE DATE:
10th World Congress on Alternatives and Animal Use in the Life Sciences
August 20-24, 2017
Seattle, Washington

CAAT Academy
Hands-on Training in Quantitative Human Cell and Effect-based In Vitro Bioanalysis for Assessing Endocrine-disrupting Compounds (EDCs)
September 7-8. 2017
Amsterdam
 

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