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Alternative Methods in Toxicology

Volume 2 - Acute Toxicity Testing: Alternative Approaches

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers


Table of Contents

Part One: Acute Toxicity Testing

  1. Acute Toxicity Testing, Purpose
    Gerhard Zbinden
  2. Acute Toxicity Testing, Practice
    Thomas E. Hickey
  3. Regulatory Uses of Acute Toxicity Data
    Paul H. LaFlamme
  4. The FRAME Research Programme on In Vitro Cytotoxicology
    Michael Balls and James W. Bridges
  5. Hazard Identification with Small Numbers of Animals: Implications for Risk Assessment
    Victor G. Laites and Ronald W. Wood

Part Two: Poster Presentations

  1. In Vitro Cytotoxicity Assays as Potential Alternatives to the Draize Ocular Irritancy Test
    C. Shopsis, E. Borenfreund, J. Walberg, and D. Star
  2. The Toxicity of Sixteen Metallic Compounds in Chinese Hamster Ovary Cells: A Comparison with Mice and Drosophila
    A.W. Hsie, R.L. Schenley, E.-L. Tan, W.E. Perdue, M.W. Williams, T.L. Hayden, and J.E. Turner
  3. Development of an In Vitro Test for Cytotoxicity in Vaginal Tissue: Effect of Ethanol on Prostanoid Release
    N.H. Dubin, M.C. DiBlasi, C.L. Thomas, and M.C. Wolff
  4. An Assessment of the Importance of Number of Dosage Levels, Number of Animals per Dosage Level, Sex and Method of LD50, and Slope Calculation in Acute Toxicity Studies
    L.R. DePass, R.C. Myers, E.V. Weaver, and C.S. Weil
  5. An In Vitro Novel Technique for Screening Antifote Potentiality of Drugs
    K.S. Swami and K.S. Jagannatha Rao
  6. Methodology Updating of Acute Toxicity Testing
    R. Bass, H.P. Gelbke, C. Gloxhuber, H. Greim, P. Gunzel, D. Henscler, A. Hildebrandt, D. Kayser, J. Konig, D. Lorke, D. Neubert, E. Schultz, D. Schuppan, G. Zbinden

Poster Abstracts

  1. Validation of a Structure-Activity Model of Rat Oral LD50
    T. Lander, K. Enslein, P. Craig, and M. Tomb
  2. An Up-and-Down Procedure for Acute Toxicity Testing
    Robert D. Bruce

Part Three: Workshops

  1. Charge to Workshops: Definitions and Goals
    Alan Goldberg
  2. Opening Statement of Workshops:
    • Statistical Considerations and Protocols Using Small Numbers of Animals. Introductory Remarks
      Gerard Zbinden
    • Species and Host Factors in Safety Evaluation
      Gareth M. Green
    • The Preselection or Establishment of a Hierarchy of Chemicals in Safety Evaluation
      Warren Muir
    • Protocol Development and the Scientific and Clinical Uses of Acute Toxicity Data
      David A. Blake
  3. Summaries of Workshops:
    • Statistical Considerations and Protocols Using Small Numbers of Animals. Introductory Remarks
      Charles Rohde
    • Species and Host Factors in Safety Evaluation
      John A. Moore
    • The Preselection or Establishment of a Hierarchy of Chemicals in Safety Evaluation
      Robert Squire
    • Protocol Development and the Scientific and Clinical Uses of Acute Toxicity Data
      Paul Kotin

Part Four: Regulatory Implications

  1. Summary: Regulatory Implications
    W. Gary Flamm

New ALTEX: 2/2018

ALTEX cover 51
 

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MeetingS

 
Building a Better Epithelium: Breaking the Barrier to the Next Generation of Toxicity Testing
March 10, 2018
San Antonio, TX

SOT Satellite Meeting: Updates on Activities Related to 21st Century Toxicology and Related Efforts: Invited Presentations and Open Mic
March 15, 2018
San Antonio, TX

SAVE THE DATE!
Social Housing Workshop
June 4-5, 2018
Beltsville, MD
Email: kherrma1@jhu.edu

SAVE THE DATE!
2nd Pan-American Conference for Alternative Methods
August 23-24, 2018
Rio de Janeiro, Brazil 

Eurotox 2018
September 2-5, 2018
Brussels, Belgium

20th International Congress on In Vitro Toxicology (ESTIV2018)
October 15-18, 2018
Berlin
 

More Meetings...