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Alternative Methods in Toxicology

Volume 2 - Acute Toxicity Testing: Alternative Approaches

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers

Table of Contents

Part One: Acute Toxicity Testing

1. Acute Toxicity Testing, Purpose
   Gerhard Zbinden
2. Acute Toxicity Testing, Practice
   Thomas E. Hickey
3. Regulatory Uses of Acute Toxicity Data
   Paul H. LaFlamme
4. The FRAME Research Programme on In Vitro Cytotoxicology
   Michael Balls and James W. Bridges
5. Hazard Identification with Small Numbers of Animals: Implications for Risk Assessment
   Victor G. Laites and Ronald W. Wood

Part Two: Poster Presentations

1. In Vitro Cytotoxicity Assays as Potential Alternatives to the Draize Ocular Irritancy Test
   C. Shopsis, E. Borenfreund, J. Walberg, and D. Star
2. The Toxicity of Sixteen Metallic Compounds in Chinese Hamster Ovary Cells: A Comparison with Mice and Drosophila
   A.W. Hsie, R.L. Schenley, E.-L. Tan, W.E. Perdue, M.W. Williams, T.L. Hayden, and J.E. Turner
3. Development of an In Vitro Test for Cytotoxicity in Vaginal Tissue: Effect of Ethanol on Prostanoid Release
   N.H. Dubin, M.C. DiBlasi, C.L. Thomas, and M.C. Wolff
4. An Assessment of the Importance of Number of Dosage Levels, Number of Animals per Dosage Level, Sex and Method of LD50, and Slope Calculation in Acute Toxicity Studies
   L.R. DePass, R.C. Myers, E.V. Weaver, and C.S. Weil
5. An In Vitro Novel Technique for Screening Antifote Potentiality of Drugs
   K.S. Swami and K.S. Jagannatha Rao
6. Methodology Updating of Acute Toxicity Testing
   R. Bass, H.P. Gelbke, C. Gloxhuber, H. Greim, P. Gunzel, D. Henscler, A. Hildebrandt, D. Kayser, J. Konig, D. Lorke, D. Neubert, E. Schultz, D. Schuppan, G. Zbinden

Poster Abstracts

1. Validation of a Structure-Activity Model of Rat Oral LD50
   T. Lander, K. Enslein, P. Craig, and M. Tomb
2. An Up-and-Down Procedure for Acute Toxicity Testing
   Robert D. Bruce

Part Three: Workshops

1. Charge to Workshops: Definitions and Goals
   Alan Goldberg
2. Opening Statement of Workshops:
   • Statistical Considerations and Protocols Using Small Numbers of Animals. Introductory Remarks
     Gerard Zbinden
   • Species and Host Factors in Safety Evaluation
     Gareth M. Green
   • The Preselection or Establishment of a Hierarchy of Chemicals in Safety Evaluation
     Warren Muir
   • Protocol Development and the Scientific and Clinical Uses of Acute Toxicity Data
     David A. Blake
3. Summaries of Workshops:
   • Statistical Considerations and Protocols Using Small Numbers of Animals. Introductory Remarks
     Charles Rohde
   • Species and Host Factors in Safety Evaluation
     John A. Moore
   • The Preselection or Establishment of a Hierarchy of Chemicals in Safety Evaluation
     Robert Squire
   • Protocol Development and the Scientific and Clinical Uses of Acute Toxicity Data
     Paul Kotin

Part Four: Regulatory Implications

1. Summary: Regulatory Implications
   W. Gary Flamm