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Alternative Methods in Toxicology

Volume 3 - In Vitro Toxicology: A Progress Report from the Johns Hopkins Center for Alternatives to Animal Testing

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers

Table of Contents

Part One: Symposium Presentations

1. Receptor Binding Techniques in Drug Development
   Solomon H. Snyder
2. Development of In Vitro Techniques to Measure the Inflammatory Response
   • Chairman's Introduction
     Peter A. Ward
   • Determination of Photosensitivity by an In Vitro Assay as an Alternative to Animals Testing
     D.J. McAuliffe, T. Hasan, J.A. Parrish, and I.E. Kochevar
   • Prostaglandin Production as an Index of In Vitro Cytotoxicity
     Norman H. Dubin
   • Surface Topography and Tight Junctional Organization of Epithelial Cells
     Michael A. Edidin, Markus Ammann, and Laura Major
   • An In Vitro Screen for Potential Inflammatory Agents Using Cultured Fibrolblasts
     H. Lei, K. Carroll, L.-C. Au, and S.S. Krag
   • Chairman's Summary
     Gareth M. Green
3. Cytotoxicity - Acute Toxicity
   • Chairman's Introduction
     Donald Reed
   • Protective Effects of Calcium in the Amelioration of Cadmium-Induced Cytotoxicity in Cultured Murine Parenchymal Hepatocytes
     Elsie M.B. Sorensen and Daniel Acosta
   • An In Vitro Model for Acute Toxicity Screening Using Hepatocytes Freshly Isolated from Adult Mammals
     G. Krack, P. Vossen, D. Deboyser, F. Goethals, and M. Roberfroid
   • Use of Primary Hepatocyte Cultures for Studies on the Toxicological Significance of Peroxisome Proliferation
     T.J.B. Gray, B.G. Lake, J.A. Beamand, and S.D. Gangolli
   • Specific Protein Synthesis as an Indicator of Cellular Injury
     John M. Frazier
   • Chairman's Summary
     Leon Golberg
4. Cell and Organ Specific Responses
   • Chairman's Introduction
     Andrew Rowan
   • The Use of Renal Medullary Cell Cultures as Alternatives to Live Animals for Studying Renal Medullary Toxicity
     S.E. Benns, M. Dixit, I. Ahmed, C. Ketley, and P.H. Bach
   • Inhibition of Organic Acid/Base Transport in Isolated Rabbit Renal Tubules by Nephrotoxins
     L.A. Rylander, A.J. Gandolfi, and K. Brendel
   • Arrhythmogenicity of Volatile Compounds in Beating Heart Cell Cultures
     D.J. Miletich, S. Holshouser, and R.F. Albrecht
   • The Establishment of In Vitro Systems to Evaluate Neuronal Toxicity
     Harvey S. Singer and Michael Tiemeyer
   • Lymphocyte Toxicity Induced by Chlorphentermine
     L.J. Sauers, D. Wierda, E.R. Walker, and M.J. Reasor
   • Use of Amniotic Fluid Cells for Testing Teratogens
     Nicole Bournias-Vardiabasis
   • Chairman's Summary
     Paul Kotin
5. Alternatives to the Draize Eye Test
   • Chairman's Introduction
     David Maurice
   • Macroscopic Assay of Focal Injury in the Chorioallantoic Membrane
     J. Leighton, R. Tchao, J. Verdone, and J. Nassauer
   • Comparison of Several Alternative Assays for Measuring Potential Toxicants
     D.M. Stark, E. Borenfreund, J. Walberg, and C. Shopsis
   • A Tissue Culture Model of the Human Corneal Epithelium
     Marcia M. Jumblatt and Arthur H. Neufeld
   • An In Vitro Alternative to the Draize Test
     Kwan Y. Chan
   • Chairman's Summary
     James McCulley
6. Technology Transfer in Toxicology
   David J. Brusick

Part Two: Poster Presentations

1. The Effects of Time on Cytotoxicity Testing In Vitro Using Primary Cultures of Adult Rat Hepatocytes
   Brian I. Carr
2. Neurotoxic Esterase in Cultured Cells: An In Vitro Alternative for the Study of Organophosphorous Compound-Induced Delayed Neurotoxicity
   C.D. Carrington, M.N. Carrington, and M.B. Abou-Donia
3. Surfactant-Induced Primary Irritancy: An In Vitro Model
   V.A. De Leo, L.C. Harber, B. Kong, and S. De Salva