Skip Navigation

Alternative Methods in Toxicology

Volume 4 - A Critical Examination of Alternatives to Acute Ocular Irritation Testing

John M. Frazier, Shayne C. Gad, Alan M. Goldberg, James P. McCulley

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers

Table of Contents


Contributing Authors


  1. Summary and Recommendations
  2. Historical Perspective on Eye Irritation Testing
  3. Current In Vivo Testing Protocols, Procedures, and Practices
  4. Adequacy of Current In Vivo Methods
  5. Potential Approaches for the Development of In Vitro Alternatives to Eye Irritancy Tests
    A. Morphology
    B. Cellular Toxicity
    C. Cell and Tissue Physiology
    D. Inflammation/Immunity E. Recovery/Repair
  6. Critical Evaluation of Alternative Tests
    A. Introduction
    B. Criteria for Test Evaluation
    C. Test Protocols
  7. Validation


New ALTEX: 3/2017
ALTEX 3/2017 cover

Support ALTWEB, Make a Gift
Online Humane Science Course


FRAME Training School in Experimental Design and Statistical Analysis
May 31-June 2, 2017
Saskatoon, Canada

Advances in Cell and Tissue Culture 2017
May 22-24, 2017
Manchester, UK

CAAT Academy
In Vitro Skin and Eye Models Hands-on Training
June 1-2 2017
Brussels, Belgium

CAAT Academy
Tools for Read-Across
June 15-16, 2017
Helsinki, Finland

ecopa SSCT Workshop 2017
June 14-16, 2017
Helsinki, Finland
Thomas Hartung will deliver a keynote address

CAAT Academy
Updates on Hepatotoxicity AOP Landscape and on the ADME Field - Season 2
June 22-23, 2017
Rennes, France

9th Euro-Global Summit on Toxicology and Applied Pharmacology
June 22-24, 2017
Paris, France
Email for Details

6th Annual Meeting of the American Society for Cellular and Computational Toxicology (ASCCT)
September 21-22
College Park, MD

10th World Congress on Alternatives and Animal Use in the Life Sciences
August 20-24, 2017
Seattle, Washington

CAAT Academy
Hands-on Training in Quantitative Human Cell and Effect-based In Vitro Bioanalysis for Assessing Endocrine-disrupting Compounds (EDCs)
September 7-8. 2017

More Meetings...