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Alternative Methods in Toxicology

Volume 5 - In Vitro Toxicology: Approaches to Validation

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers


Table of Contents

Preface

Acknowledgements

Contributing Authors

Part One: Symposium Presentations

  • Theoretical Approaches to Validation
    Robert A. Scala
  • Validation as Applied to In Vitro Toxicology
    John O. Rundell
  • The Interplay Among Validation, Policy, and Regulation
    Richard N. Hill
  • Diffusion of a New Methodology
    Frank Baker
  • Validation Studies in Progress
    1. Validation Studies on a Battery of Potential In Vitro Alternatives to the Draize Test
      Charles Shopsis, Ellen Borenfreund, and Dennis M. Stark
    2. The FRAME Approach to the Development, Validation, and Evaluation of In Vitro Alternatives Methods
      Michael Balls, Rosemary J. Riddell, Steven A. Horner, and Richard H. Clothier
    3. The Development and Evaluation of the Chorioallantoic Membrane (CAM) Assay
      Betty M. Kong, Chris J. Viau, Perveen Y. Rizvi, and Salvatore J. De Salva
    4. An Approach to Validation: Comparison of Six Materials in Three Tests
      John A. Shadduck, James Render, Jeffrey Everitt, Rose Ann Meccoli, and Diane Essex-Sorlie
    5. Validation of an In Vitro Eye Irritancy Test: A First Step
      Herman B.W.M Koeter and Menk K. Prinsen
    6. The Validation Approach of The Johns Hopkins Center for Alternatives to Animal Testing
      John M. Frazier
  • Skin and Eye Studies in Progress
    1. Chairman's Remarks
      Direct Toxicity to the Cornea: A Nonspecific Process?
      David Maurice
    2. Introductory Lecture: Mechanisms of Inflammation in Skin and Eyes - Similarities and Differences
      Michael B. Berman
    3. Two New In Vitro Methods for Evaluating Toxicity to Skin (Employing Short-Term Organ Culture): I. Paranuclear Vacuolization, Seen in Glycol Methacrylate Tissue Sections; II. Inhibition of 14C-Leucine Incorporation
      Arthur M. Dannenberg, Jr., K. Gregory Moore, Brian H. Schofield, Kazuyuki Higuchi, Akira Kajiki, Kin-Wing Au, Peggy J. Pula, and David P. Bassett
    4. Surfactant-Induced Cutaneous Primary Irritancy: An In Vitro Model
      Vincent A. DeLeo, Lauren Midlarsky, Leonard C. Harber, Betty M. Kong, and Salvatore De Salva
    5. Corneal Epithelial Wound Closure: A Tissue Culture Model of Ocular Irritancy
      Marcia M. Jumblatt, Sandra J. Simmons, and Arthur H. Neufield
    6. Further Testing of an In Vitro Phototoxicity Assay
      Irene E. Kochevar, Andre Western, and Daniel J. McAuliffe
    7. Novel Strategies for Evaluating the Comparative Toxicity of Unmodified Viscoelastic Formulations
      Dale R. Meyer and James P. McCulley
    8. A Simple Fluorometer for Use with a Permeability Screen for Immediate Ocular Toxicity
      Darrell Brooks and David Maurice
  • Special Lecture
    Development and Validation of an Alternative Test for the Detection of Embryonic Malformations: The Postimplantation Embryo Culture Test (PECT)
    Beat P. Schmid and L. Cicurel
  • Conclusions
    1. The Economic Viability of In Vitro Testing Techniques
      Henry R. Hertzfield and Thomas D. Meyers
    2. Alternatives - A Kaleidoscope of Perspectives
      Andrew N. Rowan

Part 2: Poster Presentations

  1. Cellular Uptake and Response of Primary Cultures of Rabbit Renal Proximal Tubule Cells Exposed to Mercuric Chloride and Methylmercury Chloride
    Michael D. Aleo, Mary L. Traub, James R. Olsen, Peter A. Nickerson, and Paul J. Kostyniak
  2. The Use of Primary Hepatocyte Cultures to Detect the Induction of Hepatic Alkaline Phosphate Enzyme in the Rat
    David E. Amacher and Donna J. Smith
  3. Occular Irritancy Evaluated In Vivoby Conjunctival Lavage Technique and In Vitro by Bovine Eye Cup Model
    C.A. Benassi, M.R. Angi, L. Salvalaio, and A. Bettero
  4. Use of Stimulated Oxygen Consumption as a Measure of Cutaneous Perturbation
    M.G. Bird, G. Witz, R.A. Scala, and D.V. Parke
  5. Differential Response of In Vitro Vaginal Tissue to Various Test Agents
    N.H. Dubin, R.B. Ghodgaonkar, and T.H. Parmley
  6. In Vitro Detection of Cornea-Derived Leukocytic Chemotactic Factors as Indicators of Corneal Inflammation
    Salwa A. Elgebaly, Fairpour Forouhar, and Donald L. Kreutzer
  7. Some problems in Validating Cytotoxicity as a Correlate of Ocular Irritancy
    Christopher Flower
  8. Development, Validation, and Transfer of a New Test System Technology in Toxicology
    Shayne C. Gad, Brendan J. Dunn, Frances A. Gavigan, Christopher Reilly, and Robert D. Walsh
  9. EYTEX, An In Vitro Method for Evaluation of Ocular Irritancy
    V.C. Gordon and H.C. Bergman
  10. Empirical and Experimental Bases for Selecting the Low Volume Rabbit Eye Irritation Test as the Validation Standard for In Vitro Methods
    J.F. Griffith and F.E. Freeberg
  11. Incorporation of Species Differences in Metabolism into In Vitro Teratogenicity Testing
    Barbara F. Hales
  12. Influence of Reduced Numbers of Rabbits on the Adequacy of Eye Irritancy Tests
    N.S. Hatoum, C.L. Leach, R.D. Gibbons, D.M. Talsma, J-C. Roger, and P.J. Garvin
  13. In Vitro Methods for Assessing Cytotoxicty of Contact Lenses - Comparison with In VivoData
    C. Hecquet, X. Ronot, L. Le Naour, J.G. Josse, and M. Adolphe
  14. Intralaboratory Replication of Results Obtained in the Hydra Developmental Toxicity Screen
    Alan M. Hoberman, Eric W. Sica, Mildred S. Christian, Betty M. Kong, and Frederick R. Kirchner
  15. Chemical Structure - Transport Rate Relationships for Model Skin Lipid Membranes
    Joy Houk, Corwin Hansch, Larry L. Hall, and Richard H. Guy
  16. HET-CAM - Reproducibility Studies
    Niels-P. Luepke and Siegfried Wallat
  17. A New Teratogenic Risk Assessment Bioassay System Utilizing Marine Hydrozoans
    Vicki J. Martin
  18. Evaluation of the Comparative Toxicity of Intraocular Viscoelastic Preparations
    Dale R. Meyer and James P.McCulley
  19. Cisplatinum Toxicity in Rabbit Renal Proximal Tubule Suspensions and Precision-Cut Renal Cortical Slices
    J.S. Phelps, A.J. Gnadolfi, and K. Brendel
  20. In Vitro Enzymatic Toxicity Test Model Validity Approach
    K.S. Jagannatha Rao
  21. Use of Cultured Human Cells as Screeing Models for Antipsoriatic Drugs
    Uwe Reichert, Alain Chatelus, and Gerard Pautrat
  22. Validation of Three Cell Toxicity Tests and the Hen's Egg Test with Guinea Pig Eye and Human Skin Irritation Data
    Christoph A. Reinhardt, Martin Aeschbacher, Max Bracher, and Jochen Spengler
  23. Evaluating the Percutaneous Absorption of Polynuclear Aromatics Using In Vivoand In Vitro Techniques and Structure Activity Relationships
    Timothy A. Roy, Joseph J. Yang, and Maria H. Czerwinski
  24. A Comparison of the Toxicity of the Acrylamide, Cyclophosphamide, Chlordecone, and Diethylstilbestrol in Chinese Hamster Ovary (CHO) Cells with Their Toxicity In Vivo
    Jane Ellen Simmons, Marcus Jackson, Joellen Lewtas, and Ezra Berman
  25. Ocular Lens Organ Culture System for In Vitro Toxicology
    J.G. Sivak, D. Gershon, A. Dovrat, and J. Weerheim
  26. Clonal Cultures of RPE Cells as Sensitive Indicators of Agents Affecting Terminal Differentiation
    Sabine H.H. Swierenga, Ursula Vielkind, and Fai Lee
  27. Validation of the Becam Assay - An Eye Irritancy Screening Test
    Peter J.J.M. Weterings and Yvette H.M. van Erp

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FRAME Training School in Experimental Design and Statistical Analysis
May 31-June 2, 2017
Saskatoon, Canada

Advances in Cell and Tissue Culture 2017
May 22-24, 2017
Manchester, UK

CAAT Academy
In Vitro Skin and Eye Models Hands-on Training
June 1-2 2017
Brussels, Belgium

CAAT Academy
Tools for Read-Across
June 15-16, 2017
Helsinki, Finland

ecopa SSCT Workshop 2017
June 14-16, 2017
Helsinki, Finland
Thomas Hartung will deliver a keynote address

CAAT Academy
Updates on Hepatotoxicity AOP Landscape and on the ADME Field - Season 2
June 22-23, 2017
Rennes, France

9th Euro-Global Summit on Toxicology and Applied Pharmacology
June 22-24, 2017
Paris, France
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6th Annual Meeting of the American Society for Cellular and Computational Toxicology (ASCCT)
September 21-22
College Park, MD

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10th World Congress on Alternatives and Animal Use in the Life Sciences
August 20-24, 2017
Seattle, Washington

CAAT Academy
Hands-on Training in Quantitative Human Cell and Effect-based In Vitro Bioanalysis for Assessing Endocrine-disrupting Compounds (EDCs)
September 7-8. 2017
Amsterdam
 

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