Alternative Methods in ToxicologyVolume 5 - In Vitro Toxicology: Approaches to ValidationSeries Editor: ALAN M. GOLDBERGMary Ann Liebert, Inc. | Publishers
Table of ContentsPreface Acknowledgements Contributing Authors Part One: Symposium Presentations - Theoretical Approaches to Validation
Robert A. Scala - Validation as Applied to In Vitro Toxicology
John O. Rundell - The Interplay Among Validation, Policy, and Regulation
Richard N. Hill - Diffusion of a New Methodology
Frank Baker - Validation Studies in Progress
- Validation Studies on a Battery of Potential In Vitro Alternatives to the Draize Test
Charles Shopsis, Ellen Borenfreund, and Dennis M. Stark - The FRAME Approach to the Development, Validation, and Evaluation of In Vitro Alternatives Methods
Michael Balls, Rosemary J. Riddell, Steven A. Horner, and Richard H. Clothier - The Development and Evaluation of the Chorioallantoic Membrane (CAM) Assay
Betty M. Kong, Chris J. Viau, Perveen Y. Rizvi, and Salvatore J. De Salva - An Approach to Validation: Comparison of Six Materials in Three Tests
John A. Shadduck, James Render, Jeffrey Everitt, Rose Ann Meccoli, and Diane Essex-Sorlie - Validation of an In Vitro Eye Irritancy Test: A First Step
Herman B.W.M Koeter and Menk K. Prinsen - The Validation Approach of The Johns Hopkins Center for Alternatives to Animal Testing
John M. Frazier
- Skin and Eye Studies in Progress
- Chairman's Remarks
Direct Toxicity to the Cornea: A Nonspecific Process? David Maurice - Introductory Lecture: Mechanisms of Inflammation in Skin and Eyes - Similarities and Differences
Michael B. Berman - Two New In Vitro Methods for Evaluating Toxicity to Skin (Employing Short-Term Organ Culture): I. Paranuclear Vacuolization, Seen in Glycol Methacrylate Tissue Sections; II. Inhibition of 14C-Leucine Incorporation
Arthur M. Dannenberg, Jr., K. Gregory Moore, Brian H. Schofield, Kazuyuki Higuchi, Akira Kajiki, Kin-Wing Au, Peggy J. Pula, and David P. Bassett - Surfactant-Induced Cutaneous Primary Irritancy: An In Vitro Model
Vincent A. DeLeo, Lauren Midlarsky, Leonard C. Harber, Betty M. Kong, and Salvatore De Salva - Corneal Epithelial Wound Closure: A Tissue Culture Model of Ocular Irritancy
Marcia M. Jumblatt, Sandra J. Simmons, and Arthur H. Neufield - Further Testing of an In Vitro Phototoxicity Assay
Irene E. Kochevar, Andre Western, and Daniel J. McAuliffe - Novel Strategies for Evaluating the Comparative Toxicity of Unmodified Viscoelastic Formulations
Dale R. Meyer and James P. McCulley - A Simple Fluorometer for Use with a Permeability Screen for Immediate Ocular Toxicity
Darrell Brooks and David Maurice
- Special Lecture
Development and Validation of an Alternative Test for the Detection of Embryonic Malformations: The Postimplantation Embryo Culture Test (PECT) Beat P. Schmid and L. Cicurel - Conclusions
- The Economic Viability of In Vitro Testing Techniques
Henry R. Hertzfield and Thomas D. Meyers - Alternatives - A Kaleidoscope of Perspectives
Andrew N. Rowan
Part 2: Poster Presentations - Cellular Uptake and Response of Primary Cultures of Rabbit Renal Proximal Tubule Cells Exposed to Mercuric Chloride and Methylmercury Chloride
Michael D. Aleo, Mary L. Traub, James R. Olsen, Peter A. Nickerson, and Paul J. Kostyniak - The Use of Primary Hepatocyte Cultures to Detect the Induction of Hepatic Alkaline Phosphate Enzyme in the Rat
David E. Amacher and Donna J. Smith - Occular Irritancy Evaluated In Vivoby Conjunctival Lavage Technique and In Vitro by Bovine Eye Cup Model
C.A. Benassi, M.R. Angi, L. Salvalaio, and A. Bettero - Use of Stimulated Oxygen Consumption as a Measure of Cutaneous Perturbation
M.G. Bird, G. Witz, R.A. Scala, and D.V. Parke - Differential Response of In Vitro Vaginal Tissue to Various Test Agents
N.H. Dubin, R.B. Ghodgaonkar, and T.H. Parmley - In Vitro Detection of Cornea-Derived Leukocytic Chemotactic Factors as Indicators of Corneal Inflammation
Salwa A. Elgebaly, Fairpour Forouhar, and Donald L. Kreutzer - Some problems in Validating Cytotoxicity as a Correlate of Ocular Irritancy
Christopher Flower - Development, Validation, and Transfer of a New Test System Technology in Toxicology
Shayne C. Gad, Brendan J. Dunn, Frances A. Gavigan, Christopher Reilly, and Robert D. Walsh - EYTEX, An In Vitro Method for Evaluation of Ocular Irritancy
V.C. Gordon and H.C. Bergman - Empirical and Experimental Bases for Selecting the Low Volume Rabbit Eye Irritation Test as the Validation Standard for In Vitro Methods
J.F. Griffith and F.E. Freeberg - Incorporation of Species Differences in Metabolism into In Vitro Teratogenicity Testing
Barbara F. Hales - Influence of Reduced Numbers of Rabbits on the Adequacy of Eye Irritancy Tests
N.S. Hatoum, C.L. Leach, R.D. Gibbons, D.M. Talsma, J-C. Roger, and P.J. Garvin - In Vitro Methods for Assessing Cytotoxicty of Contact Lenses - Comparison with In VivoData
C. Hecquet, X. Ronot, L. Le Naour, J.G. Josse, and M. Adolphe - Intralaboratory Replication of Results Obtained in the Hydra Developmental Toxicity Screen
Alan M. Hoberman, Eric W. Sica, Mildred S. Christian, Betty M. Kong, and Frederick R. Kirchner - Chemical Structure - Transport Rate Relationships for Model Skin Lipid Membranes
Joy Houk, Corwin Hansch, Larry L. Hall, and Richard H. Guy - HET-CAM - Reproducibility Studies
Niels-P. Luepke and Siegfried Wallat - A New Teratogenic Risk Assessment Bioassay System Utilizing Marine Hydrozoans
Vicki J. Martin - Evaluation of the Comparative Toxicity of Intraocular Viscoelastic Preparations
Dale R. Meyer and James P.McCulley - Cisplatinum Toxicity in Rabbit Renal Proximal Tubule Suspensions and Precision-Cut Renal Cortical Slices
J.S. Phelps, A.J. Gnadolfi, and K. Brendel - In Vitro Enzymatic Toxicity Test Model Validity Approach
K.S. Jagannatha Rao - Use of Cultured Human Cells as Screeing Models for Antipsoriatic Drugs
Uwe Reichert, Alain Chatelus, and Gerard Pautrat - Validation of Three Cell Toxicity Tests and the Hen's Egg Test with Guinea Pig Eye and Human Skin Irritation Data
Christoph A. Reinhardt, Martin Aeschbacher, Max Bracher, and Jochen Spengler - Evaluating the Percutaneous Absorption of Polynuclear Aromatics Using In Vivoand In Vitro Techniques and Structure Activity Relationships
Timothy A. Roy, Joseph J. Yang, and Maria H. Czerwinski - A Comparison of the Toxicity of the Acrylamide, Cyclophosphamide, Chlordecone, and Diethylstilbestrol in Chinese Hamster Ovary (CHO) Cells with Their Toxicity In Vivo
Jane Ellen Simmons, Marcus Jackson, Joellen Lewtas, and Ezra Berman - Ocular Lens Organ Culture System for In Vitro Toxicology
J.G. Sivak, D. Gershon, A. Dovrat, and J. Weerheim - Clonal Cultures of RPE Cells as Sensitive Indicators of Agents Affecting Terminal Differentiation
Sabine H.H. Swierenga, Ursula Vielkind, and Fai Lee - Validation of the Becam Assay - An Eye Irritancy Screening Test
Peter J.J.M. Weterings and Yvette H.M. van Erp
| New ALTEX:1/2018
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MeetingS | Building a Better Epithelium: Breaking the Barrier to the Next Generation of Toxicity Testing March 10, 2018 San Antonio, TX SOT Satellite Meeting: Updates on Activities Related to 21st Century Toxicology and Related Efforts: Invited Presentations and Open Mic March 15, 2018 San Antonio, TX SAVE THE DATE! Social Housing Workshop June 4-5, 2018 Beltsville, MD Email: kherrma1@jhu.edu SAVE THE DATE! 2nd Pan-American Conference for Alternative Methods August 23-24, 2018 Rio de Janeiro, Brazil Eurotox 2018 September 2-5, 2018 Brussels, Belgium 20th International Congress on In Vitro Toxicology (ESTIV2018) October 15-18, 2018 Berlin More Meetings... |
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