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Alternative Methods in Toxicology

Volume 6 - Progress in In Vitro Toxicology

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers

Table of Contents

Preface

Acknowledgements

Contributing Authors

Part One: Sympopsium Presentations

• Epidermal Toxicity
  1. Skin Toxicity
     L.A. Goldsmith
  2. Proteinase Biology in Keratinocyte Culture: Possible Utility as a Model for Toxicological Testing
     G.S. Lazarus
  3. Testskin: A Hybrid Organism Covered by a Living Human Skin Equivalent DEsigned for Toxicity and Other Testing
     E. Bell, N.L. Parenteau, H.B. Haimes, R.J. Gay, P.D. Kemp, T.W. Fofonoff, V.S. Mason, D.T. Kagan, and M. Swiderek
  4. Cellular Responses of Cultured Human Epidermal Keratinocytes as Models of Toxicity to Human Skin
     S.T. Boyce, J.F. Hansborough, and D.A. Norris
  5. Surfactant-Induced Cutaneous Primary Irritancy: An In Vitro Model - Assay System Development
     V. DeLeo, J. Hong, S. Schiede, B. Kong, S. De Salva, and D. Bagley
  6. Summary of Panel Discussion
     Y. Gressel
• Recent Advances in Tissue Culture
  1. Introduction
     P. Ward
  2. Cultured Endothelial Cells as Probes for In Vitro Biology
     U.S. Ryan and J.M. Vann
  3. Cultured Rat Hepatocytes in the Study of the Hepatoxicity of Acetaminophen
     J.L. Farber
• Update: A Critical Evaluation of Alternatives to Acute Ocular Irritancy Testing
  J.M. Frazier
• Biotechnology and In Vitro Toxicology
  1. Issues in the Dafety Assessment of Products of Biotechnology
     G. Zbinden
  2. Recombitant DNA and Monoclonal Antibody Products
     R.E. Stoll
  3. Tests for Worker Exposure to Products of Biotechnology
     D.K. Flaherty, P.A. Winzenburger, and P.L. Sherman
  4. Summary
     R.A. Scala

Part 2: Poster Presentations

• Poster Presentations
  1. Functional Characteristics of Proximal Tubule Cells in Primary Culture: A New In Vitro Model for Studying Nephrotoxocity
     M.D. Aleo and P.J. Kostyniak
  2. Structure-Activity Relationship of Inorganic Metals, Organometals, and Organic Test Agents Determined In Vitro with the Neutral Red Assay
     H. Babich and E. Borenfreund
  3. An Imrproved CAM Assay for Predicting Ocular Irritation Potential
     D.M. Bagley, P.Y. Rizvi, B.M. Kong, and S.J. De Salva
  4. The Effects of Hyperoxic and Hypoxic Exposure on Catalase in Mouse Skin Explants
     M.G. Bird, G. Witz, R.A. Scala, and D.V. Parke
  5. Prediction of the Eye Irritation Potential of Surfactant-Based Household Cleaning Products Using the SIRC Cell Toxicity Test
     J. Demetrulias and H. North-Root
  6. Differential Response of In Vitro Vaginal Tissue to Various Test Agents
     N.H. Dubin, R.B. Ghodgaonkar, and T.H. Parmley
  7. Use of Isolated Hepatocytes for Studying the Biochemical Mechanisms of Steatosis and Cholestasis
     F. Goethals, D. Deboyser, C. Gonzalez, and M. Roberfroid
  8. The Use of Freshly Isolated Hepatocytes for Studying Toxicity of Drug Mixtures
     F. Goethals, P. Vossen, M.-N. Blaude, and M. Roberfroid
  9. Comparative Hazard Assessment of Formaldehyde and Trioxane In Vitro Using Human Diploid Cell Strains
     R.A. Kreiger and V.F. Garry
  10. High Performance Liquid Chromatography Analysis of the Novel Neutrophil Chemoattractants "Nourin" Released from Alkali-Burned Corneas
      F. Metwally, A. Cohen, E.F. Rossomando, and S.A. Elgebaly
  11. Acute and Protracted Injury to Corneal Epithelium as an Indication of the Biocompatibility of Various Pharmaceutical Vehicles
      D.R. Meyer and J.P. McCulley
  12. In Vitro Toxicology Data on Respirable Particles and Fibres and Its Evaluation for Statistical Significance
      D. Nadeau, D. Paradis, L. Fouquette, and J. Dunnigan
  13. In Vitro Ocular Irritancy Prediction: Assays in Serum-Free Media Correlate Better with In Vivo Data
      C. Shopsis and b. Eng
  14. The MTT In VitroCytotoxicity Test: Correlation with Cutaneous Irritancy in Two Animal Models
      D.A. Swisher, M.E. Prevo, and P.W. Ledger
  15. Trans-Epithelial Permeability of Fluorescein In Vitro as an Assay to Determine Eye Irritants
      R. Tcaho
  16. In Vitro Cytotoxicity Test Using Primary Cells Derived from Rabbit Eye Is Useful as an Alternative for Draize Testing
      M. Watanabe, K. Watanabe, K. Suzuki, O. Nikaido, T. Sugahara, I. Ishii, and H. Konishi
  17. Evaluation of Organic Nephrotoxins Using Rabbit Renal Cortical Slices
      G.H.I. Wolfgang, A.J. Gandolfi, C.L. Krumdieck, and K. Brendal
  18. A Rapid and Reliable Acute Toxicity Test for Hepatotoxic Agents Using Only a Single Animal
      U. Wormser and D. Calp
• Commercial Poster Presentations
  1. The EYTEX-MPA System: An In Vitro Method for the Evaluation of Ocular Safety
     V.C. Gordon and H.C. Bergman
  2. External Evaluation of the Standard EYTEX System in Six Laboratories to Determine Intra- and Inter-Laboratory Accuracy and Precision
     V.C. Gordon and H.C. Bergman
  3. External Evaluation of the EYTEX and EYTEX-MPA Systems in Twelve Laboratories to Determine the Correlation of EYTEX Results with In Vivo Results
     V.C. Gordon and H.C. Bergman
  4. Current Uses of Normal Human Epidermal Keratinocytes in Serum-Free Medium for In Vitro Toxicology
     P.T. Wagner