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Alternative Methods in Toxicology

Volume 7 - In Vitro Toxicology: New Directions

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers

Table of Contents

Preface

Acknowledgements

Contributing Authors

Part One: Sympopsium Presentations

• Use of In Vitro Methods in Product Development
  1. In Vitro Approaches to Drug Discovery
  2. Use of In Vitro Assays to Define the Malignant Activities of Tumor Cells and to Screen for Antimetastatic Drugs
     R. Reich, S.H. Adler, G.R. Martin, and L.S. Royce
  3. Development of Alternatives in a Consumer Product Company
     J. Yam and R. Winters
  4. Summary
     O.P. Flint
• Progress Report from the CAAT on Neurptoxicity
  1. In Vitro Neurotoxicity in Drug Discovery and Development
     R.E. Giles
  2. Analysis of Cell Type-Specific Neurotoxicity Using Purified Cultures of Avian and Mammalian Retinal Neurons and Photoreceptors
     R. Adler and D. Stenkamp
  3. Whole-Cell Patch-Clamp Recordings of the Responses of Cultured Rabbit Trigeminal Ganglion Neurons to Capsaicin - An Irritant and Neurotoxin
     T.K. Baumann and R.H. LaMotte
  4. Neurotoxicity of Dopamine-Selective Drugs
     M.K. Conrad, M.M.S. Lo, and M.J. Kadan
  5. In Vitro Neurotoxicity Testing of Cancer Chemotherapeutic Agents Using Cerebellar Explant Cultures
     M.R. Gilbert and S.A. Grossman
  6. Permanent Differentiated Cell Lines from Human Biopsy Material
     O. Hurko
  7. Summary
     D.O. Allen
• Toxicology, In Vitro Methods, and Alternatives
  E.A. Pfitzer
• The Development of Insulin Assays Without the Use of Animals
  J. Trethewey
• In Vitro Approaches to Immunotoxicology
  1. An Introduction to the Immune System
     N.R. Rose
  2. In Vitro Analysis of Chemical Toxicity Directed Toward Bone Marrow-Derived Macrophages and Stromal Cells: The Impact on B-Cell Lymphopoiesis
     D. Wierda
  3. Characterization of In Vivo and In Vitro Chemical Exposure and Immunization Approaches for Assessing Effects on Acquired Immunity
     M.J. Murray and J.H. Dean

Part 2: Poster Presentations

• Dermal Toxicity
  1. Comparisons of the Cytotoxicities of Dermatotoxicants to Human Keratinocytes and Fibrinoblasts In Vitro
     H. Babich, N. Martin-Alguacil, and E. Borenfreund
  2. Flow Cytometric Analysis of Toxicity by Alkylating Agents in Human Epidermal Keratinocytes
     Y.A. Gales, C.L. Gross, R.C. Krebs, and W.J. Smith
  3. Developing an Alternative to the Draize Skin Test: Comparison of Human Skin Cell Responses to Irritants In Vitro
     G.S. Lamont, D.M. Bagley, B.M. Kong, and S.J. De Salva
  4. A Physiological Skin Model for In Vitro Toxicity Studies
     G.K. Naughton, L. Jacob, and B.A. Naughton
• Hepatic Toxicity
  1. Evaluation of Various Parameters in Testing Drug Cytotoxicity in Primary Hepatocyte Cultures
     C. Chesne, C. Clerc, C. Guyomard, A. Fautrel, and A. Guillouzo
  2. Development of a Juvenile Catfish (Ictalurus punctatus) Primary Hepatocyte Culture for Aquatic Toxicity Testing
     P.F. Dehn and N. Wohlschlag
  3. Cytotoxic Response of a Juvenile Catfish (Ictalurus punctatus) Primary Hepatocytes to Cadmium
     R. Garcia, F. Morales, N. Wohlschlag, and P.F. Dehn
  4. Cytotoxic and Post Isolation Recovery Time Responses of Juvenile Catfish (Ictalurus punctatus) Primary Hepatocytes to Mercury Chloride
     R. Garcia, F. Morales, N. Wohlschlag, and P.F. Dehn
  5. Hepatocyte Cocultures as a Model for the Study of Long-Term, Selective, and Reversible Toxic Effects of Drugs
     D. Ratanasavanh, R. Bulson, A.M. Barthel, and A. Guillouzo
  6. The Liver Slice System: A Simple Acute Toxicity Test for Evaluation of Hepatotoxic Agents
     U. Wormser, S. Ben-Zakine, E. Stivelband, and A. Nyska
• Immunotoxicity
  1. In Vitro Assays for Chemicals and Drugs Causing Immunomodulation in Fish
     D.P. Anderson, O.W. Dixon, and A.K. Siqicki
  2. Suspended Nylon Screen Long-Term Bone Marrow Cultures as Substrates for Cytotoxicity Determinations
     B.A. Naughton, R.A. Preti, and G.K. Naughton
  3. Flow Cytometric Analysis of Peripheral Blood Lymphocytes for the Assessment of Toxicity by Alkylating Agents
     K.M. Sanders, J.K. Innace, C.L. Gross, and W.J. Smith
• Ocular Toxicity
  1. Assessing the Eye Irritation Potential of Surfactant-Based Materials Using the Chorioallantoic Membrane Vascular Assay (CAMVA)
     D.M. Bagley, B.M. Kong, and S.J. De Salva
  2. Validation Study: Ocular Irritancy Prediction with the Total Cell Protein, Uridine Uptake, and Neutral Red Assays Applied to Human Epidermal Keratinocytes and Mouse 3T3 Cells
     C. Shopsis
  3. Evaluation of an Alternative Method for Ocular Irritation
     R.J. soto, M.J. Servi, and V.C. Gordon
  4. Evaluation of the Neutral Red Cytotoxicity Assay as a Predictive Test for the Ocular Irritancy Potential of Cosmetic Products
     M.A. Thomson, L.A. Hearn, K.T. Smith, J.J. Teal, and M.S. Dickens
• Reproductive/Developmental Toxicity
  1. Proteoglycan and Procollagen Syntheses in Rat Embryo Limb Bud Cultures Treated with Quinolone Antibacterials
     D.E. Amacher, S.J. Schomaker, T.D. Gootz, and P.R. McGuirk
  2. Primary Hepatocyte Culture as an Activating System for Xenobiotica Tested in the Rat Whole Embryo In Vitro
     R. Bechter, P. Bouis, and V. Fischer
• Other
  1. The Prediction of Phototoxic Potential Using Human A431 Cells and Mouse 3T3 Cells
     P.A. Duffy, A. Bennett, M. Roberts, and O.P. Flint
  2. Applications of the EYTEX Method for Determination of the Ocular Irritation of Surfactant Formulations
     V.C. Gordon, C.P. Kelly, and H.C. Bergman
  3. Toxicological Recognition of Replicate Casts
     A.L. Patra
  4. Isolation, Culture, and Characterization of Human Renal Papillary Collecting Duct Cells
     A.L. Trigillis, X. Yi, and M.W. Kahng
  5. Interlaboratory Validation Study of the Keratinocyte Neutral Red Bioassay from Clonetics Corporation
     D. Triglia, P.T. Wegener, J. Harbell, K. Wallace, D. Matheson, and C. Shopsis
• SUMMARY OF MEETING
  O.P. Flint