Alternative Methods in ToxicologyVolume 7 - In Vitro Toxicology: New DirectionsSeries Editor: ALAN M. GOLDBERGMary Ann Liebert, Inc. | Publishers
Table of ContentsPreface Acknowledgements Contributing Authors Part One: Sympopsium Presentations - Use of In Vitro Methods in Product Development
- In Vitro Approaches to Drug Discovery
- Use of In Vitro Assays to Define the Malignant Activities of Tumor Cells and to Screen for Antimetastatic Drugs
R. Reich, S.H. Adler, G.R. Martin, and L.S. Royce - Development of Alternatives in a Consumer Product Company
J. Yam and R. Winters - Summary
O.P. Flint
- Progress Report from the CAAT on Neurptoxicity
- In Vitro Neurotoxicity in Drug Discovery and Development
R.E. Giles - Analysis of Cell Type-Specific Neurotoxicity Using Purified Cultures of Avian and Mammalian Retinal Neurons and Photoreceptors
R. Adler and D. Stenkamp - Whole-Cell Patch-Clamp Recordings of the Responses of Cultured Rabbit Trigeminal Ganglion Neurons to Capsaicin - An Irritant and Neurotoxin
T.K. Baumann and R.H. LaMotte - Neurotoxicity of Dopamine-Selective Drugs
M.K. Conrad, M.M.S. Lo, and M.J. Kadan - In Vitro Neurotoxicity Testing of Cancer Chemotherapeutic Agents Using Cerebellar Explant Cultures
M.R. Gilbert and S.A. Grossman - Permanent Differentiated Cell Lines from Human Biopsy Material
O. Hurko - Summary
D.O. Allen
- Toxicology, In Vitro Methods, and Alternatives
E.A. Pfitzer - The Development of Insulin Assays Without the Use of Animals
J. Trethewey - In Vitro Approaches to Immunotoxicology
- An Introduction to the Immune System
N.R. Rose - In Vitro Analysis of Chemical Toxicity Directed Toward Bone Marrow-Derived Macrophages and Stromal Cells: The Impact on B-Cell Lymphopoiesis
D. Wierda - Characterization of In Vivo and In Vitro Chemical Exposure and Immunization Approaches for Assessing Effects on Acquired Immunity
M.J. Murray and J.H. Dean
Part 2: Poster Presentations - Dermal Toxicity
- Comparisons of the Cytotoxicities of Dermatotoxicants to Human Keratinocytes and Fibrinoblasts In Vitro
H. Babich, N. Martin-Alguacil, and E. Borenfreund - Flow Cytometric Analysis of Toxicity by Alkylating Agents in Human Epidermal Keratinocytes
Y.A. Gales, C.L. Gross, R.C. Krebs, and W.J. Smith - Developing an Alternative to the Draize Skin Test: Comparison of Human Skin Cell Responses to Irritants In Vitro
G.S. Lamont, D.M. Bagley, B.M. Kong, and S.J. De Salva - A Physiological Skin Model for In Vitro Toxicity Studies
G.K. Naughton, L. Jacob, and B.A. Naughton
- Hepatic Toxicity
- Evaluation of Various Parameters in Testing Drug Cytotoxicity in Primary Hepatocyte Cultures
C. Chesne, C. Clerc, C. Guyomard, A. Fautrel, and A. Guillouzo - Development of a Juvenile Catfish (Ictalurus punctatus) Primary Hepatocyte Culture for Aquatic Toxicity Testing
P.F. Dehn and N. Wohlschlag - Cytotoxic Response of a Juvenile Catfish (Ictalurus punctatus) Primary Hepatocytes to Cadmium
R. Garcia, F. Morales, N. Wohlschlag, and P.F. Dehn - Cytotoxic and Post Isolation Recovery Time Responses of Juvenile Catfish (Ictalurus punctatus) Primary Hepatocytes to Mercury Chloride
R. Garcia, F. Morales, N. Wohlschlag, and P.F. Dehn - Hepatocyte Cocultures as a Model for the Study of Long-Term, Selective, and Reversible Toxic Effects of Drugs
D. Ratanasavanh, R. Bulson, A.M. Barthel, and A. Guillouzo - The Liver Slice System: A Simple Acute Toxicity Test for Evaluation of Hepatotoxic Agents
U. Wormser, S. Ben-Zakine, E. Stivelband, and A. Nyska
- Immunotoxicity
- In Vitro Assays for Chemicals and Drugs Causing Immunomodulation in Fish
D.P. Anderson, O.W. Dixon, and A.K. Siqicki - Suspended Nylon Screen Long-Term Bone Marrow Cultures as Substrates for Cytotoxicity Determinations
B.A. Naughton, R.A. Preti, and G.K. Naughton - Flow Cytometric Analysis of Peripheral Blood Lymphocytes for the Assessment of Toxicity by Alkylating Agents
K.M. Sanders, J.K. Innace, C.L. Gross, and W.J. Smith
- Ocular Toxicity
- Assessing the Eye Irritation Potential of Surfactant-Based Materials Using the Chorioallantoic Membrane Vascular Assay (CAMVA)
D.M. Bagley, B.M. Kong, and S.J. De Salva - Validation Study: Ocular Irritancy Prediction with the Total Cell Protein, Uridine Uptake, and Neutral Red Assays Applied to Human Epidermal Keratinocytes and Mouse 3T3 Cells
C. Shopsis - Evaluation of an Alternative Method for Ocular Irritation
R.J. soto, M.J. Servi, and V.C. Gordon - Evaluation of the Neutral Red Cytotoxicity Assay as a Predictive Test for the Ocular Irritancy Potential of Cosmetic Products
M.A. Thomson, L.A. Hearn, K.T. Smith, J.J. Teal, and M.S. Dickens
- Reproductive/Developmental Toxicity
- Proteoglycan and Procollagen Syntheses in Rat Embryo Limb Bud Cultures Treated with Quinolone Antibacterials
D.E. Amacher, S.J. Schomaker, T.D. Gootz, and P.R. McGuirk - Primary Hepatocyte Culture as an Activating System for Xenobiotica Tested in the Rat Whole Embryo In Vitro
R. Bechter, P. Bouis, and V. Fischer
- Other
- The Prediction of Phototoxic Potential Using Human A431 Cells and Mouse 3T3 Cells
P.A. Duffy, A. Bennett, M. Roberts, and O.P. Flint - Applications of the EYTEX Method for Determination of the Ocular Irritation of Surfactant Formulations
V.C. Gordon, C.P. Kelly, and H.C. Bergman - Toxicological Recognition of Replicate Casts
A.L. Patra - Isolation, Culture, and Characterization of Human Renal Papillary Collecting Duct Cells
A.L. Trigillis, X. Yi, and M.W. Kahng - Interlaboratory Validation Study of the Keratinocyte Neutral Red Bioassay from Clonetics Corporation
D. Triglia, P.T. Wegener, J. Harbell, K. Wallace, D. Matheson, and C. Shopsis
- SUMMARY OF MEETING
O.P. Flint
| New ALTEX:1/2018
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MeetingS | Building a Better Epithelium: Breaking the Barrier to the Next Generation of Toxicity Testing March 10, 2018 San Antonio, TX SOT Satellite Meeting: Updates on Activities Related to 21st Century Toxicology and Related Efforts: Invited Presentations and Open Mic March 15, 2018 San Antonio, TX SAVE THE DATE! Social Housing Workshop June 4-5, 2018 Beltsville, MD Email: kherrma1@jhu.edu SAVE THE DATE! 2nd Pan-American Conference for Alternative Methods August 23-24, 2018 Rio de Janeiro, Brazil Eurotox 2018 September 2-5, 2018 Brussels, Belgium 20th International Congress on In Vitro Toxicology (ESTIV2018) October 15-18, 2018 Berlin More Meetings... |
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