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Alternative Methods in Toxicology

Volume 8 - In Vitro Toxicology: Mechanisms and New Technology

Series Editor: ALAN M. GOLDBERG

Mary Ann Liebert, Inc. | Publishers

Table of Contents

Preface

Acknowledgements

Contributing Authors

Part One: Symposium Presentations

• Mechanisms of Tissue Injury
  1. Arachidonic Acid Metabolites and Phagocytic Cells as Mediators of Tissue Injury
     H.J. Forman and T.W. Robison
  2. Molecular Studies of n-Hexane and Carbon Disulfide Neuropathies
     D.G. Graham, W.M. Valentine, V. Amarnath, and D.C. Anthony
• Avon Contact Allergy Program Project Update
  1. Introduction to Avon Program Project
     J.J. Teal
  2. The Skin as an Immunologic Organ: Role of Epidermal Cytokines
     D.N. Auder and C. Feliciani
• Application of Molecular Biology and Genetics to In Vitro Toxicology
  1. Stimulation of Cell Proliferation by Tumor Promoters
     J.D. Yager
  2. Molecular Mechanisms of Adrenergic Responses
     J.J. Onotatio
  3. Development of an In Vitro Model System to Study the Physiologic Effects and Toxicities of Immunosuppressants
     C.B. Thompson, K.M. Jackson, L.A. Turka, B.S. Mitchell, and C.H. June
• Reproductive Toxicology and Teratology
  1. In Vitro Assessment of Gamete Integrity
     S.P. Darney
  2. In Vitro Approaches to Teratology
     B.F. Hales
• Historical Perspectives on In Vitro Toxicology
  J. Parascandola
• New Technology
  1. Cells on Silicon: The Microphysiometer
     J.W. Parce, J.C. Owicki, H.G. Wada, and K.M. Kercsco
  2. In Vitro Mutagenesis Assay Developed through Genetic Engineering
     N.S. Rudolph, V.B. Reddy, and C. Wei
• Extrapolation
  1. The Role of Physiological Modeling in Reducing Animal Use in Toxicology Research
     K. Krishnan and M.E. Andersen
  2. In Vitro - In Vivo Extrapolation of Xenobiotic Metabolism
     R.J. Chernery, J.P. Keogh, L.C. Rath, and P. McWilliams
  3. An Expert System Approach to the Prediction and Elucidation of the Structural Basis of Toxicological Activities
     H.S. Rosenkranz and G. Klopman
  4. Comparative Toxicity: Mechanistic Studies on Acetaminophen Action In Vitro and In Vivo in Various Studies Including Man
     C.A. Tyson, S.D. Cohen, and E.A. Khairallah
• Alternative Methods for Toxicity Testing: Perspectives on Validation in Europe
  B.J. Blaauboer
• Update on Validation - 1990
  J.M. Frazier

Part 2: Poster Presentations

• Liver
  1. Long-Term Liver Cell Cultures as Potential Substrates for Toxicity Assessment
     B.A. Naughton, B. Sibanda, and G.K. Naughton
  2. Effects of Indole Derivatives on Biotransformation Activities in Primary Cultures of Rat Hepatocytes
     H.M. Wortelboer, C.A. de Kruif, F.R. Cassee, H.E. Falker, A.A.J. Wortelboer, C.A. de Kruif, F.R. Cassee, H.E. Falke, A.A.J. van Iersel, J. Noordhoek, and B.J. Blaauboer
• Ocular Toxicity
  1. An Evaluation of the SIRC Rabbit Corneal Cell System for the Estimation of Ocular Irritancy Potential
     D.E. Amacher, C.V. Higgins, and R. Jayasinghe
  2. A Comparison of the In Vitro and In Vivo Effects of Nonionic Surfactants Used in Ophthalmic Formulations
     R.M. Oda, M.P. Wong, I.-M. Pride, M. Ismail, J. Andersen, C. Anger, and S. Matsumoto
  3. Evaluation of the EYTEX System as a Screen for Eye Irritancy of Petroleum Products
     T.A. Roy, K.A. Saladdin, J.J. Yang, and V.C. Gordon
  4. Occular Irritancy Prediction via Light Scattering Measurements on Chicken Cornea
     C. Shopsis, T. Zhao, and F.A. Bettelheim
  5. EYTEX Third Generation
     V.C. Gordon
  6. The SOLATEX System, An In Vitro Method to Predict Photoirritation and Screen SPF Formation
     V.C. Gordon and C.P. Kelly
• Dermal Toxicity
  1. Response of Human Cell Cultures to Cytotoxicants Requiring Metabolic Activation
     H. Babich, N. Martin-Alguacil, C. Raul, D.W. Rosenberg, and E. Borenfreund
  2. Arachidonic Acid-Release from Three Skin Culture Models in Response to Surfactant-Based Irritants
     M.P. Carver, R. Reigle, and S.J. DeSalva
  3. Rapid Structural and Functional Evaluation of Epidermal Cell Cultures Using Laser Scanning Confocal Microscopy
     C. Cullander, R.H. Guy, R. Hinz, P. Biblbo, C. Nolte, L.M. Wilkins, and N.L. Parenteau
  4. A Comparison of Four Measures of Toxicity Applied to Human Dermal Fibroblasts Grown in Three Dimensional Culture on Nylon Mesh (SKIN2 Dermal Model)
     J.W. Harbell, K.A. Wallace, R.D. Curren, G.K. Naughton, and D. Triglia
  5. Native-State Sponge-Gel Histoculture of Intact Three Dimensional Tissue for In Vitro Toxicity Assays
     L. Li, L.B. Margolis, and R.M. Hoffman
  6. Evaluation of Human Skin Cell Cultures for In Vitro Skin Irritancy Testing
     R. Osborne and M.A. Perkins
  7. Role of Epidermal Keratinocytes During Contact Allergy
     F.M. Robertson and T.M Oberyszyn
  8. Regulation of Collagen Deposition by Human Fibroblasts Grown in a Three Dimensional Skin Culture System
     S.R. Slivka, L. Landeen, G.K. Naughton, and R.L. Bartel
  9. Evaluation of an In Vitro Dermal Irritation Assay
     R.J. Soto and V.C. Gordon
  10. A Three Dimensional Human Dermal Model Substrate for In Vitro Toxicological Studies
      D. Triglia, S.S. Braa, T. Donnelly, I. Kidd, and G.K. Naughton
  11. A New Two-Compartment Skin Model for Cutaneous Toxicity Testing
      J.J.M. van de Sandt, A.A.J.J.L. Rutten, and H.B.W.M. Koeter
• Mechanisms of Toxicity
  1. Difloxacin Reduces Glycosaminoglycan Sunthesis in Organ Cultures of Articular Cartilage
     J. Burkhardt, M. Hill, W. Carlton, and C. Lamar
  2. An In Vitro Assessment of Determinants of Susceptibility of Mouse Bone Marrow Stromal Cells to Hydroquinone-Induced Toxicity
     L.E. Twerdok, S.J. Rembish, and M.A. Trush
  3. Assessing Psychoative Drug Neurotoxicity In Vitro: Initial Studies Using NG108-15 Neuroblastoma-Glioma Cells
     A.D. Weissman and J.E. Johnson, Jr.
• Reproductive/Developmental Toxicity
  1. Leydig Cell Primary Cultures Can Be Used to Identify Toxicants Acting to Impair or Kill Leydig Cells
     W.R. Kelce, B.R. Zirkin, and L.L. Ewing
• Development of New In Vitro Systems
  1. Comparison of Cell, Tissue, and Whole Organism Bioassays to Assess Inorganic Metal Toxicity in the Aquatic Environment
     A.S. Kane, R.O. Bennett, J.H. Resau, J.R. Cottrell, R. Reimschuessel, E.B. May, M. Streb, R. Hutchenson, and M.M. Lipsky
  2. Rat Nasal Epithelial Cell Lines for In Vitro Toxicity Testing: Derivation and Partial Characterization
     P.M. Mattes, W.B. Mattes, and J.B. Morris
  3. Isolated Whole Heart and Tissue Culture Models for the Study of Arrhythmias
     J. Morgan and L. Cohen
  4. Measurement of Hematotoxicity Using Bone Marrow Cultured Alone or in the Presence of Liver Cell Cultures
     B.A. Naughton, B. Silbanda, D. Triglia, and G.K. Naughton
  5. Lucigenin-Derived Chemiluminescence as a Monitor of Mitochondrial Maturation and Modulation in Mononuclear Cells
     S.J. Rembish, Y. Yang, R.L. Esterline, A. Seacoat, and M.A. Trush
  6. Utility of Neuronal Tissue Cultures at Defence Research Establishment Suffield
     T.W. Sawyer and M.T. Weiss
• Other
  1. Computer Simulation Studies of Systmeic Physiology and Pharmacology
     R.L. Summers and J.P. Montani