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Volume 38 Number 1 March 2010 EDITORIAL Replacing the animal testing of botulinum toxin: time to smooth out the wrinkles M. Balls NEWS & VIEWS
ECVAM NEWS & VIEWS ARTICLES Application of the improved BALB/c 3T3 Cell Transformation Assay to the examination of the initiating and promoting activities of chemicals: the second inter-laboratory collaborative study by the Non-genotoxic Carcinogen Study Group of Japan T. Tsuchiya, M. Umeda, N. Tanaka, A. Sakai, H. Nishiyama, I.Yoshimura, S. Ajimi, S. Asada, M. Asakura, H. Baba, Y. Dewa, Y. Ebe,Y. Fushiwaki, Y. Hagiwara, S. Hamada, T. Hamamura, Y. Iwase, Y. Kajiwara, Y. Kasahara, Y. Kato, M. Kawabata, E. Kitada, K. Kaneko, Y. Kizaki, K. Kubo, D. Miura, K. Mashiko, F. Mizuhashi, D. Muramatsu, M. Nakajima, T. Nakamura, H. Oishi, T. Sasaki, S. Shimada, C. Takahashi, Y. Takeda, S. Wakuri, N. Yajima, S. Yajima & T. Yatsushiro An estimation of the extent of animal use in research in Brazil, as determined by bibliographic sampling from journals published in the State of Paraná V.C.B. Silla, E.C. de Oliveira Sans & C.F.M. Molento Experience with the HET-CAM method in the routine testing of a broad variety of chemicals and formulations A. Schrage, A.O. Gamer, B. van Ravenzwaay & R. Landsiedel Laboratory animal science in China: current status and potential for the adoption of Three R alternatives Q. Kong & C. Qin The use of organotypic hippocampal slice cultures to evaluate protection against excitotoxicity by non-competitive NMDA receptor antagonists A. Ring, R. Tanso & J. Noraberg LETTER
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