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Proceedings for "Alternatives in Monoclonal Antibody Production"

September 24-25, 1997 | Baltimore, MD

A workshop of The Johns Hopkins Center for Alternatives to Animal Testing and The Office for Protection from Research Risks, National Institutes of Health


Presentation of the Issue
Nelson Garnett, DVM, Director, Division of Animal Welfare, Office for Protection from Research Risks, NIH
John McArdle, PhD, Director, Alternatives Research & Development Foundation

Scientific Presentations: State-Of-The-Science Methods For Mab Production--Advantages and Disadvantages

"Overview: The Science and Uses of Monoclonal Antibodies"
Mark Soloski, PhD, Associate Professor of Rheumatology, Johns Hopkins University School of Medicine

"Hollow Fiber Bioreactors: An Alternative to the Use of Mice for MAB Production"
Neil S. Lipman, VMD, Director of the Research Animal Resource Center and Associate Professor of Pathology, Cornell University Medical College and the Memorial Sloan-Kettering Cancer Center

"Comparison of Hollow Fiber Bioreactors and Modular Minifermentors for the Production of MABs In Vitro"
Howard T. Petrie, PhD, Assistant Member, Immunology Program Director, Monoclonal Antibody Core Facility, Memorial Sloan-Kettering Cancer Center

"The Use of Gas-Permeable Bags for MAB Production"
Jerry R. Heidel, DVM, Associate Professor, College of Veterinary Medicine, Oregon State University

"Practical Applications and Comparison of Ascites and In Vitro Methods for MAB Production"
Norman C. Peterson, DVM, MS, Research Associate in Pathology and Laboratory Medicine, University of Pennsylvania Medical School

"Ascites Alternatives: A Comparison of Lab-Scale Production of Monoclonal Antibodies in the Unisyn Cell-Pharm System 100 and the miniPERM Bioreactor"
Frank W. Falkenberg, Professor, Ruhr-Universitat Bochum, Germany

Special Lecture: "Animal Welfare Concerns about Monoclonal Antibody Production"
Andrew N. Rowan, DPhil, Senior Vice President, Humane Society of the United States

Panel Presentations and Discussion: IACUCS--Responsibilities and Needs in Advising Investigators

Marcia Etheridge, DVM, Assistant Professor of Comparative Medicine, JHU School of Medicine

Lou DeTolla, VMD, PhD, Director of Comparative Medicine Programs and Chief of Veterinary Resources, University of Maryland School of Medicine

DeWayne H. Walker, DVM, Manager of Laboratory Animal Research Services, 3M Corporation

Core Laboratories: What is Their Cost-Effectiveness and What are Their Needs?

Margaret B. Penno, PhD, Associate Professor of Medicine, JHU School of Medicine

Panel Presentation and Discussion: Regulatory Issues in the United States

Summary

Louis R. Sibal, PhD, Director, Office of Laboratory Animal Research, NIH

Jerry D. DePoyster, DVM, Veterinary Medical Officer, U.S. Department of Agriculture

William S. Stokes, DVM, Associate Director, Animals and Alternatives, National Institute of Environmental Health Sciences and Director, Interagency Coordinating Committee on the Validation of Alternative Methods

The European Perspective

Coenraad Hendriksen, DVM, PhD, National Institute of Public Health and Environmental Protection, The Netherlands

Recommendations

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