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Proceedings for Pain Management and Humane Endpoints

A workshop of
The Johns Hopkins Center for Alternatives to Animal Testing
National Institutes of Health Office for Protection from Research Risks
The National Institutes of Health Office for Animal Care and Use
and
The National Academy of Sciences Institute for Laboratory Animal Research

November 2-3, 1998
National Academy of Sciences Auditorium
2101 C Street, NW
Washington, DC

INTRODUCTION AND WELCOME

• Ralph B. Dell, ILAR, NAS

OVERVIEW OF ISSUE

• Science
  Gerald F. Gebhart, University of Iowa
• Philosophical and Ethical Issues Concerning Pain
  David DeGrazia, George Washington University
• Opinion Research on Animal Experimentation: Areas of Support and Concern
    Scott Plous, Wesleyan University

SCIENCE

• Assessment of Pain and Distress in Laboratory Animals
    Jeri Sechzer, Pace University and UMDNJ
• Pain Assessment in Children
    Charles B. Berde, Children's Hospital, Boston
• Alleviation of Pain in Laboratory Animals
    Paul Flecknell, University of Newcastle, UK
• Alleviation of Animal Pain: Clinical Applications
    Dennis R. Geiser, University of Tennessee--presenting for Charles Short
• Arriving at a Biological Definition of Stress and Distress
    Gary Moberg, University of California at Davis

POLICY

• Pain Management and Humane Endpoints: PHS Policy Perspective
    Nelson L. Garnett, NIH, OPRR
• Animal Welfare Act--Requirements for the Minimization of Pain and Distress
    W. Ron DeHaven, USDA, APHIS
• Multinational Agreements/International Harmonization
    John G. Miller, AAALAC International
• The Triple A Approach to Assure Animal Welfare
    Judith Davis, AHCS, DIR, NINDS, NIH
• Animal Welfare Perspectives on Pain and Distress Management in Research and Testing
    Andrew N. Rowan, Humane Society of the United States
• IACUC and Pain-Related Internet Resources
    Kenneth R. Boschert, Washington University

IMPLEMENTATION

• IACUC Responsibilities: Reviewing Potentially Painful Procedures
    Ralph B. Dell, ILAR/NAS
• Implementing Assessment Techniques  David B. Morton, University of Birmingham, UK

ENDPOINTS

• Canadian Council on Animal Care Guidelines on: Choosing an Appropriate Endpoint in Experiments Using Animals in Research Teaching and Testing
    Jim H. Wong, Canadian Council on Animal Care
• Endpoints in Infectious Disease and Cancer Models
    Ernest Olfert, University of Saskatchewan, Canada
• Monitoring of Genetic Engineering Studies
    Melvin B. Dennis, Jr., University of Washington
• Humane Endpoints for Laboratory Animals Used in Toxicology Testing
    William S. Stokes, NIEHS/ICCVAM

PANEL DISCUSSION--Q&A

• Humane Endpoints in the OECD--An Update
    Alan M. Goldberg JHU, CAAT