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Local Lymph Node Assay

Table of Contents

1. Test Submission
   1. Cover Letter
   2. Submission
2. Appendices
   1. Local Lymph Node Assay Bibliography
   2. List of Chemicals
      1. Chemicals Tested in Local Lymph Node Assay
      2. Discordant Results Between Local Lymph Node Assay and Guinea Pig or Human Test Methods
      3. Disintegrations Per Minute Data and Stimulation Indices for Discordant Results
   3. Key Local Lymph Node Assay Papers
   4. Sample Local Lymph Node Assay Protocol
   5. ICCVAM Local Lymph Node Assay Test Submission Guidelines

Local Lymph Node Assay References Included in ICCVAM Submission

1. Basketter, D.A. and E.W. Scholes (1992). Comparison of the Local Lymph Node Assay with the guinea pig maximization test for the detection of a range of contact allergens. Fd. Chem. Toxic. 30: 65-69.
2. Basketter, D.A., Selbie, E., Scholes, E.W., Lees, D., Kimber, I., and P.A. Botham (1993). Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node assays. Fd. Chem. Toxic. 31: 63-67.
3. Basketter, D.A., Scholes, E.W., and I. Kimber (1994). The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Fd. Chem. Toxic. 32: 543-547.
4. Basketter, D.A., Gerberick, G.F., Kimber, I., and S.E. Loveless (1996). The local lymph node assay: a viable alternative to currently accepted skin sensitization tests. Fd. Chem. Toxic. 34: 985-997.
5. Basketter, D.A., Gerberick, G.F., and I. Kimber. Strategies for identifying false positive responses in predictive skin sensitization tests. Fd. Chem. Toxic. Accepted for publication.
6. Chamberlain, M. and D.A. Basketter (1996). The local lymph node assay: status of validation. Fd. Chem. Toxic. 34: 999-1002.
7. Gerberick, G.F., House, R.V., Fletcher, R.E., and C.A. Ryan (1992). Examination of the local lymph node assay for use in contact sensitization risk assessment. Fund. Appl. Toxicol. 19: 438-445.
8. Kimber, I., Hilton, J., Dearman, R.J., Gerberick, G.F., Ryan, C.A., Basketter, D.A., Scholes, E.W., Ladies, G.S., Loveless, S.E., House, R.V., and A. Guy (1995). An international evaluation of the murine local lymph node assay and comparison of modified procedures. Toxicology 103: 63-73.
9. Kimber, I., Hilton, J., Dearman, R.J., Gerberick, G.F., Ryan, C.A., Basketter, D.A., Lea, L., House, R.V., Ladies, G.S., Loveless, S.E., and K.L. Hastings (1998). Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory exercise. J. Toxicol. Environ. Health 53(7): 563-579.
10. Loveless, S.E., Ladies, G.S., Gerberick, G.F., Ryan, C.A., Basketter, D.A., Scholes, E.W., House, R.V., Hilton, J., Dearman, R.J., and I. Kimber (1996). Further evaluation of the local lymph node assay in the final phase of an international collaborative trial. Toxicology 108: 141-152.