Proceedings of the 6th World Congress on Alternatives & Animal Use in the Life SciencesTokyo, Japan ? March 31, 2008
Japanese Society for Alternatives to Animal Experiments (JSAAE) 
All files are in PDF format and require Adobe Acrobat Reader. - Cover
- Acknowledgements
- Contents
- Author Index
- Professor W.M.S. Russell (1925?2006): Doyen of the Three Rs
Michael Balls,
?? FRAME, Russell & Burch House, UK - Three Rs in mutation research?From in vivo to in silico evaluation
Makoto Hayashi
? National Institute of Health Sciences, Japan - Exploring new approaches to assess safety without animal testing
Julia Fentem, Paul Carmichael, Gavin Maxwell, Camilla Pease, Fiona Reynolds, Guy Warner and Carl Westmoreland
? Unilever?Safety & Environmental Assurance Centre, UK - Alternative research and practice supported by international veterinary professionals
Judy MacArthur Clark
? International Association of Colleges of Laboratory Animal Medicine, USA - The science of alternatives: 25 years and tomorrow
Alan M. Goldberg
? The Johns Hopkins University, USA - A UK example of balanced inquiry into the ethics of animal experimentation
Baroness Perry of Southwark
? Nuffield Council on Bioethics Working Party and University of Surrey, UK - Mission and accomplishments of ZEBET, the national centre for alternatives in Germany at the BfR (Federal Institute for Risk Assessment)
Horst Spielmann, Barbara Grune, Manfred Liebsch Andrea Seiler and Richard Vogel
? National Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments, Germany - Standards for the rearing environment of laboratory animals in the United States
Kathryn Bayne
? AAALAC International, USA - Standards of accommodation and care for animals used in scientific procedures in Europe
David B. Anderson
? Animals (Scientific Procedures) Inspectorate, UK - The standards of the rearing environment for laboratory animals in Japan
Hiroo Hachisu
? Nihon University, Japan - Animal rights in Islam
Reza Gharebaghi1, Mohammad Reza Vaez Mahdavi2, Hasan Ghasemi2, Amir Dibaei3?and Fatemeh Heidary1
? 1Middle East Breast Cancer Institute, 2Shahed University, Medical School, 3Ahvaz University of Medical Sciences, Iran - An investigation in the use of forage grains for laboratory rats
Michael Rowntree
? Covance Laboratories Ltd., UK - Collaboration between academia and industry with focus on improvement of the welfare of both animals and humans in laboratory animal facilities
Jan Lund Ottesen1, Lars Friis Mikkelsen1, Thomas Bertelsen2, Thomas Krohn3, Sten Velschow4, Jann Hau3, Henrik M?llegaard5, Nils Dragsted1?and Axel Kornerup Hansen3
? 1Novo Nordisk A/S, 2LEO Pharma, 3University of Copenhagen, 4?Lundbeck A/S, 5Scanbur A/S, Denmark - A holistic approach to taking research animal suffering seriously
Martin L. Stephens and Kathleen Conlee
? The Humane Society of the United States, USA - Fetal 'awareness' and 'pain': What precautions should be taken to safeguard fetal welfare during experiments?
David James Mellor1?, Tamara Johanna Diesch1?, Alistair Jan Gunn2??and Laura Bennet2
?? 1?Massey University, 2?University of Auckland, New Zealand - The development of a national guideline to promote the wellbeing of animals used for scientific purposes
Elizabeth Grant, David Adams, Steve Atkinson, Simon Bain, Mary Bate, Lynda Bonning, Wendy Fahy, Denise Noonan and Margaret Rose
National Health & Medical Research Council, Australia - Tramadol minimizes potential pain during post-oophorectomy in Wistar rats
Maria Angelica Guzman-Silva, Carlos Eduardo Pollastri, Jose Augusto Soares Pantale?o, Ana Carolina Bergmann de Carvalho, Helene Nara Henriques, Natersia Rosa Camara, Juliana Tomaz Pacheco and Gilson Teles Boaventura
? Fluminense Federal University, Brazil - Does distress matter?
Judy MacArthur Clark
? Institute for Laboratory Animal Research, The National Academies, USA - Innovative refinements to anaesthesia techniques can deliver pain research without pain
Craig Brian Johnson1?, Jo Murrell2?, Troy John Gibson1??and David James Mellor1
?? 1?Massey University, 2?University of Bristol, New Zealand - Why does carbon dioxide produce analgesia?
Ken-ichi Otsuguro, Sumiko Yasutake, Yoshihiko Yamaji, Masaaki Ban, Toshio Ohta and Shigeo Ito
? Hokkaido University, Japan - Implementation of permanent group housing for cynomolgus macaques on a large scale
for regulatory toxicology studies
Janet L. Kelly
? Covance Laboratories Ltd., UK - Chimpanzees in research and testing worldwide: Overview, oversight and applicable laws
Kathleen M. Conlee
? The Humane Society of the United States, USA - Chimpanzee experiments: Questionable contributions to biomedical progress
Andrew Knight
? Animal Consultants International, UK - Systematic reviews of animal experiments demonstrate poor human utility
Andrew Knight
? Animal Consultants International, UK - Promoting consideration of the ethical aspects of animal use and implementation of the 3Rs
Barney T. Reed and Maggy Jennings
? RSPCA, UK - Effect of policy decisions on experimental animal use in the UK
Derek J. Fry
? Animals Scientific Procedures Inspectorate, Home Office, UK - Genetically modified animals in the biomedical sciences: The challenge of rapid advances & ethical demands
Margaret Rose1 , Elizabeth Grant2 and David Adams2
1 University of New South Wales, 2 National Health & Medical Research Council, Australia - Pain-free animals: An acceptable refinement?
Renee M. Gardner and Alan M. Goldberg
? Johns Hopkins Bloomberg School of Public Health, USA - Facilitation of an international approach for data sharing and acquisition in relation to genetically-engineered animals
Gilly Griffin and Cl?ment Gauthier
? Canadian Council on Animal Care, Canada - The institutional animal care committee: Keystone of international harmonization
Cl?ment Gauthier
? Canadian Council on Animal Care, Canada - A review of trends in animal use in the United States (1972 ? 2006)
Jodie Kulpa-Eddy1?, Margaret Snyder2??and William Stokes1
?? 1?U.S. Department of Agriculture, 2?U.S. Department of Health and Human Services, USA - Does regulation drive, manage or monitor change?
Jon Richmond
? Home Office, UK - An analysis of reporting pain and distress recognition and alleviation in scientific journal publications
Leah M. Gomez and Kathleen M. Conlee
? The Humane Society of the United States, USA - Japanese concept and government policy on animal welfare and animal experiments
Katsuhiko Shoji
? Toyo University, Japan - Guidelines for proper conduct of animal experiments by the Science Council of Japan
Hideaki Karaki
? Science Council of Japan, Japan - Research animals for scientific purposes in Thailand: Ethics & policies
Pattamarat Kunjara and Pradon Chatikavanij
? The National Research Council of Thailand, Thailand - Public participation in decisions relating to the use of animals for scientific purposes: A review of 20 years
experience in Australia
Margaret Rose, Lynette Chave and Peter Johnson
? University of New South Wales, Australia - Public participation in informed decision-making on animal use in Canada
Cl?ment Gauthier and Gilly Griffin
? Canadian Council on Animal Care, Canada - AALAS resources and programs supporting the 3 R?s and humane concepts in animal research
Nicole E. Duffee and Ann T. Turner
? American Association for Laboratory Animal Science, USA - Is it possible to meet the learning objectives of undergraduate pharmacology classes with non-animal models?
David Dewhurst
? University of Edinburgh, UK - Humane teaching methods prove efficacious within veterinary and other biomedical education
Andrew Knight
? Animal Consultants International, UK - Role of simulator in surgical blood pressure
Nimgulkar Chetan Chandrakant, Patil Savita Dattatray and Surana Sanjay
? R. C. Patel College of Pharmacy, India - Outreach, alternatives awareness and replacement in Russia
Elena Maroueva1??and Nick Jukes2
?? 1?InterNICHE-Russia & VITA, Russia,2??InterNICHE, Leicester, England, England - Three Rs in the research and education system of Pakistan: Perspectives and possibilities
Hafsa Zaneb and Christian Stanek
? Veterinary Medicine University, Austria - A prototype software to sensitize medical undergraduate students to animal research methodology
Ramasamy Raveendran
? Jawaharlal Institute of Postgraduate Medical Education & Research, India - A new model for developing computer-based alternatives to using animals in tertiary education
David Dewhurst, Stewart Cromar and Rachel Ellaway
? University of Edinburgh, UK - BioSafaris: A rationale for educational software on human biology and health in pre-college as an alternative to dissection
Lynette A. Hart1?, Mary W. Wood1?, David Wiley2?, Bernd Hamann1?, Marco Molinaro1?, Stuart Meyers1, Frazier T. Stevenson1??and William A. Storm3
?? 1?University of California, Davis, 2?Stratovan Corporation, 3?Davis Joint Unified School District, Davis, USA - From policy to practice: Illustrating the viability of full replacement
Siri Martinsen1??and Nick Jukes2
?? 1?InterNICHE Norway, Norway, 2?InterNICHE, Leicester, England, UK - Education and training system in Japanese research laboratories in a global pharmaceutical company
Makoto Suzuki
? Ina Research Inc., Japan - Future alternatives in ?3Rs?: Learning from history
Tohru Inoue and Yukio Kodama
? National Institute of Health Sciences, Japan - The effect of the Middle East conflict on the use of animals in training, research and testing in Israel
Tamir Lousky
? InterNICHE ? The International Network for Humane Education, Israel - Ethically sourced animal cadavers and tissue: Considerations for education and training
Siri Martinsen1??and Nick Jukes2
?? 1?InterNICHE Norway, Norway, 2?InterNICHE, Leicester, England, England - Training the animal doctor: Caring as a clinical skill
Siri Martinsen
? InterNICHE Norway, Norway - Guidelines for the development of student choice policies regarding dissection in colleges and universities: An ethnographic analysis of faculty and student concerns
Laura Ducceschi1?, Lynette A. Hart2??and Nicole Green1
?? 1?Animalearn, 2?University of California, Davis, USA - Facilitating replacement through access to and training in alternatives
Monika Percic?1?, Nick Jukes2??and Elena Maroueva3
?? 1?InterNICHE Alternatives Loan System, Ljutomer, Slovenia, Slovenia, 2?InterNICHE, Leicester, England, UK, 3?InterNICHE Russia & VITA, Russia - InterNICHE Humane Education Award: Assessing the international impact
Nick Jukes1??and Siri Martinsen2
?? 1?InterNICHE, Leicester, England, UK, 2?InterNICHE Norway, Norway - E-Learning?A new tool for the education of young scientists in the humane treatment of experimental animals: A contribution to the 3R
Nicole Steinberg1?, Eckhard von Keutz2?, J?rgen Weis3?, Gerhard Heldmaier1??and Cornelia Exner1
?? 1?University of Marburg, 2?Bayer HealthCare AG, Wuppertal-Aprath, 3IBF University of Heidelberg, Germany - Three's a crowd: The 1R of replacement for education and training
Nick Jukes1??and Siri Martinsen2
?? 1?InterNICHE, Leicester, England, UK, 2?InterNICHE Norway, Norway - CAAT and Altweb: Making 3Rs information and resources available around the world
Carol J. Howard
? The Johns Hopkins Center for Alternatives to Animal Testing (CAAT), USA - ANZCCART and our strategies for sharing information
Geoffrey W. Dandie
? ANZCCART, Australia - Selecting appropriate animal models and strains: Making the best use of research, information and outreach
Mary W. Wood and Lynette A. Hart
? University of California, Davis, USA - Refinement in the literature: Searching for environmental enrichment
Kristina M. Adams
? Animal Welfare Information Center, US Department of Agriculture, USA - Web 2.0 and alternatives
Michael M. Hughes
Johns Hopkins University Center for Alternatives to Animal Testing, USA - Japanese regulation of laboratory animal care with 3Rs
Tsutomu M. Kurosawa
? Osaka University Medical School, Japan - Adopting alternative methods for regulatory testing in Canada
Allison Guy, Cl?ment Gauthier and Gilly Griffin
? Canadian Council on Animal Care, Canada - Multimedia software for demonstrating animal experiments in pharmacology
Chandragouda R. Patil
? R. C. Patel College of Pharmacy, India - U.S. perspective on the ?consideration of alternatives? regulatory requirement
Jodie Kulpa-Eddy and Kristina Adams
? Animal Welfare Information Center, US Department of Agriculture, USA - Update on the Colipa research programme for development of in vitro alternative methods
for eye irritation
Pauline McNamee1, Lieve Declercq2, Ann De Smedt3?, Bart De Wever4, Claudine Faller5?, John Harbell6, Penny Jones7, Monique Marrec-Fairley8, Wolfgang Pape9, Uwe Pfannenbecker9, Klaus Schroeder10?, Magalie Tailhardat11, Christine Van den Berghe12??and Freddy Van Goethem3
?? 1Procter & Gamble Company, UK, 2Estee-Lauder Companies, Belgium, 3Johnson & Johnson Pharmaceutical Research & Development, Germany, 4Phenion, Switzerland, 5Procter & Gamble Cosmital, USA, 6Mary Kay Inc., UK, 7Unilever, Belgium, 8COLIPA, Germany, 9Beiersdorf, Germany, 10Henkel, France, 11?LVMH, France, 12L?Oreal, Belgium - The use of the reconstructed Human Corneal Model (HCE) to assess in vitro eye irritancy of chemicals
Jos? Cotovio1, Marie-H?l?ne Grandidier1, Damien Leli?vre1, Christelle Bremond3, Nicole Flamand1, Sophie Loisel-Joubert2, Aline Van Der Lee2, Christophe Capallere3, Jean-Roch Meunier1??and Jacques Leclaire1
?? 1L?Or?al Research, 2?L?Or?al Safety Evaluation, 3?SkinEthic Laboratories, France - In vitro acute skin irritancy of chemicals using the validated EPISKIN model in a tiered strategy
Results and performances with 184 cosmetic ingredients
Jos? Cotovio1, Marie-H?l?ne Grandidier1, Damien Leli?vre1, Roland Roguet1, Estelle Tinois-Tessoneaud2?and Jacques Leclaire1
?? 1L?Or?al Research, 2SkinEthic Laboratories, France - Comparison of human skin irritation and photo-irritation patch test data with cellular in vitro assays and animal in vivo data
Dagmar Jirova1, Manfred Liebsch2, David Basketter3, Erin Spiller4, Kristina Kejlova1, Hana Bendova1, Marie Marriott5??and Helena Kandarova4
? 1National Institute of Public Health, Czech Republic,
? 2ZEBET, Federal Institute for Risk Assessment, Germany, 3St Thomas? Hospital, UK,
? 4MatTek Corporation, USA, 5Unilever Colworth Laboratory, UK - BALB/c 3T3 cell transformation assays for the assessment of chemical carcinogenicity
Ayako Sakai
? National Institute of Health Sciences, Japan - The COLIPA strategy for the development of in vitro alternatives: Skin sensitisation
Pierre Aeby1, Takao Ashikaga2, Walter Diembeck3, Dietmar Eschrich4, Frank Gerberick5, Ian Kimber6,
? Monique Marrec-Fairley7, Gavin Maxwell8, Jean-Marc Ovigne9, Hitoshi Sakaguchi10, Magalie Tailhardat11??and Silvia Teissier9
? 1Procter & Gamble, Switzerland, 2Shiseido Research Centre, Japan, 3Beiersdorf, Germany, 4Phenion GMBH (Henkel), Germany, 5Procter & Gamble, USA,
? 6Syngenta, Central Toxicology Laboratory, UK, 7COLIPA, Belgium, 8Unilever, Safety and Environmental Assurance Centre, UK, 9L?Oreal Recherche, France,
? 10Kao Corporation, Japan, 11LVMH Recherche, UK - Application of a systems biology approach for skin allergy risk assessment
Gavin Maxwell and Cameron MacKay
? Unilever?Safety & Environmental Assurance Centre, UK - The EPISKIN Phototoxicity Assay (EPA): Development of an in vitro tiered strategy to predict phototoxic potential
Damien Leli?vre1, Pascale Justine1, Fran?ois Christiaens1, Nicole Bonaventure1, Julie Coutet1,
? Laurent Marrot1, Estelle Tinois-Tessonneaud2?and Jos? Cotovio1
? 1L?Or?al Research, 2SkinEthic Laboratories, France - In vitro cytotoxicity assessment of selected nanoparticles using human skin fibroblasts
Fin Dechsakulthorn, Amanda Hayes, Shahnaz Bakand, Lucky Joeng and Chris Winder
? The University of New South Wales, Australia - Genotoxicity assays with Episkin?, a reconstructed skin model: Towards new tools for in vitro risk assessment of dermally applied compounds?
Gladys Ou?draogo1, Michelle Feltes1, Linda Bourouf1, Nicole Flamand1, Estelle Tinois-Tessoneaud2??and Jean-Roch Meunier1
?? 1L?Or?al Safety Research Department, 2SkinEthic Laboratories, France - Percutaneous absorption test?A case of effectiveness evaluation of skin-whitening cosmetics
Tooru Koike1, Noriko Nakashima1, Chinami Urata1, Masaki Arashima1, Hidenobu Okumura1??and Akiyoshi Takada2
? 1NOEVIR, Co. Ltd., 2Osaka University, Japan - Monocyte derived dendritic cells as a tool to predict skin sensitization: Limitations and opportunities
Dietmar Eschrich1, Ursula Engels1, Julia Scheel2??and Klausrudolf Schroeder1
? 1Phenion GmbH & Co.KG, 2Henkel KGaA, Corporate SHE and Product Safety/Human Safety Assessment, Germany - Study on the prediction of human lip irritation from cosmetics materials using HeLa-MTT assay
Miyuki Morinaga, Kenta Shingaki, Tatsumi Mori and Koji Yanagihara
? NOEVIR Co., Ltd., Japan - Assessment of the in vitro skin irritation of chemicals using the Vitrolife-Skin? human skin model
Noriyuki Morikawa, Tatsuya Kitagawa and Kenji Tomihata
? GUNZE Ltd., Japan - Validation of alternative endpoints for the LLNA: General considerations
Silvia Casati
? ECVAM, IHCP, Joint Research Centre, European Commission, Italy - Validation studies on an alternative endpoint for the local lymph node assay (LLNA-DA): Importance of study management
Takashi Omori1, Yoshiaki Ikarashi2, Yukiko Kanazawa3, Kenji Idehara4, Hajime Kojima2, Takashi Sozu5, Kazunori Arima6, Hirohiko Goto7, Tomohiko Hanada8, Taketo Inoda9, Tadashi Kosaka10, Eiji Maki11, Takashi Morimoto12, Shinsuke Shinoda13, Naoki Shinoda14, Masahiro Takeyoshi15, Masashi Tanaka16, Mamoru Uratani17, Masahito Usami18, Atsushi Yamanaka19, Tomofumi Yoneda20, Isao Yoshimura21?and Atsuko Yuasa22
? 1Kyoto University, 2National Institute of Health Sciences, 3Food and Drug Safety Center, 4Daicel Chemical Industries Ltd., 5Osaka University, 6Taisho Pharmaceutical Co. Ltd., 7Otsuka Pharmaceutical Co. Ltd., 8Nippon Shinyaku Co. Ltd., 9Nakano Seiyaku Co. Ltd., 10Institute of Environmental Toxicology, 11Biosafety Research Center, Foods, Drugs and Pesticides,
? 12Sumitomo Chemical Co. Ltd., 13Drug Safety Testing Center Co. Ltd., 14Santen Pharmaceutical Co. Ltd., 15Chemicals Evaluation and Research Institute,
? 16Meiji Seika Kaisha Ltd., 17Ishihara Sangyo Kaisha Ltd., 18Hoyu Co. Ltd., 19Pias Corporation, 20Toaeiyo Ltd., 21Tokyo University of Science, 22Fuji Film Co. Ltd., Japan - Alternative application route in the LLNA provides crucial environmental enrichment and broadens the usability of vehicles
Ulla Festersen, Christine Rasmussen, Tanja M.R. Kjaer, Nanna K. Soni, Erwin L. Roggen and Ninna W. Berg
? Novozymes A/S, Denmark - In vitro hepatotoxicity testing in the early phase of drug discovery
Ikuo Horii and Hiroshi Yamada
? Pfizer Global Research & Development, Pfizer Inc., Japan - Genetic polymorphism in drug metabolism and toxicity: Linking animal research and risk assessment in man
Tetsuo Satoh
? Chiba University and HAB Research Institute, Japan - Renal drug transporters and nephrotoxicity
Naohiko Anzai1 and Hitoshi Endou1,2
class="style2"1Kyorin University School of Medicine, 2J-Pharma Co. Ltd., Japan - Cisplatin-induced renal injury in LLC-PK1 cells
Yoshiko Kawai1 and Munekazu Gemba2
class="style3"1Osaka University of Pharmaceutical Sciences, 2Yokohama College of Pharmacy, Japan - Predictive in vitro cardiotoxicity and hepatotoxicity screening system using neonatal rat heart cells and rat hepatocytes
Tomoaki Inoue, Kenji Tanaka, Masayuki Mishima and Kazuto Watanabe
? Chugai Pharmaceutical Co., Ltd., Japan - Toxicological and clinical computational analysis by the Informatics and Computational Safety Analysis Staff of the US FDA/CDER
Daniel R. Benz, Edwin J. Matthews, Naomi L. Kruhlak, Anna A. Frid, Barbara L. Minnier and Joseph F. Contrera
? US Food and Drug Administration, USA - Evaluation of (Q)SAR models for the prediction of mutagenicity potential
Stephanie Ringeissen, Reine Note, Catherine Dochez, Nicole Flamand, Gladys Ouedraogo-Arras and Jean-Roch Meunier
? L'Or?al Recherche, France - Internationally harmonized processes for test method evaluation, validation and regulatory acceptance:
The role of OECD guidance document 34
Leonard M. Schechtman
? Innovative Toxicology Consulting, LLC, USA - JaCVAM: An organization supporting the validation and peer review of new alternatives to animal testing
Hajime Kojima
? National Institute of Health Sciences, Japan - A new signaling pathway of dioxin receptor ligands through targeted protein degradation
Shigeaki Kato1, Yoshiaki Fujii-Kuriyama2??and Fumiaki Ohtake
? 1ERATO, Japan Science and Technology Agency, University of Tokyo, 2University of Tokyo, 3University of Tsukuba, Japan - A strategy to explore the target receptor of endocrine disruptors: Estrogen-related receptor ? (ERR?) as a genuine acceptor of Bisphenol A
Ayami Matsushima and Yasuyuki Shimohigashi
? Kyushu University, Japan - What is better experimental design for in vitro comet assay to detect chemical genotoxicity?
Yu F. Sasaki1, Takanori Nakamura2??and Satomi Kawaguchi1,3
? 1Hachinohe National College of Technology, 2Himeji Dokkyo University, 3Fuji Biomedix Co., Ltd., Japan - Comparative evaluation of cosmetic formulations with different alternative methods for eye irritation
Andreas Heppenheimer1, Albrecht Poth1, Rolf Fautz2?and Anne Fuchs2
? 1RCC Cytotest Cell Research GmbH, 2KPSS - KAO Professional Salon Services GmbH, Germany - Preliminary study on neutral red uptake assay as an alternative method for eye irritation test
Xingfen Yang1, Wengai Zhang1,2, Ying Yang2, Xikun Xiong1, Xiaoping Xie1??and Xiaohua Tan1
? 1Center for Disease Control and Prevention of Guangdong Province, 2Sun Yat-sen University, China - Establishment and use of 3t3 NRU assay for assessment of phototoxic hazard of cosmetic products
Ying Yanga1, Xikun Xiong1, Xinfen Yang1, Junming Huan1, Xiaohua Tan1, Xiaoping Xie1,
? Huisheng Zheng1, Qing Li1??and Xiwen He2
? 1Center for Disease Control and Prevention of Guangdong Province, 2Center for Disease Control and Prevention of China, China - Bhas42 cell transformation assay as a predictor of carcinogenicity
Albrecht Poth Andreas Heppenheimer and Susanne Bohnenberger
? RCC Cytotest Cells Research GmbH, Germany - ECVAM key area topical toxicity: Update on activities
Val?rie Zuang, Chantra Eskes, Claudius Griesinger and Thomas Hartung
? European Commission, Italy - Experiences in the development and utilization of an in vitro safety testing program for hair conditioners
Pushpa Vavilikolanu1, Catherine Lazaro1, Greg Mun2, Allison Hilberer2, Matthew Hyder2, Hans Raabe2, Rodger Curren2?and Gertrude-Emilia Costin2
? 1Alberto-Culver Company, 2Institute for In Vitro Sciences, Inc., USA - Protective effect of melatonin on spinal cord damage after gamma irradiation
Sara Aghazadeh1, Mahnaz Azarnia1, Alireza Shirazi2, Seied Rabie Mahdavi3??and Bagher Minaee Zangii1
? 1Tehran University of Medical Sciences, 2Tarbiat Moalem University, 3Babol University of Medical Sciences, Iran - Does preclinical testing on insects help to predict human myelotoxic potentials?
Josef Berger
? University of South Bohemia, Czech Republic - Evaluation of health risk due to the exposure to endosulfan in the environment
Melissa Pui Ling Chan, Shinsuke Morisawa, Aki Nakayama and Minoru Yoneda
? Kyoto University, Japan - Responsiveness to painful stimuli in anaesthetised newborn and young animals of varying neurological maturity (wallaby joeys, rat pups and lambs)
Tamara J. Diesch, David J. Mellor, Craig B. Johnson and Roger G. Lentle
? Massey University, New Zealand - Predicting carcinogenicity in humans: The need to supplement animal-based toxicology
Mara E. Long
? Johns Hopkins Bloomberg School of Public Health, Canada - Systemic testing by the dermal route can be precluded by new non-animal percutaneous absorption strategies
Kristie Stoick1, Ken Nitschke2??and Chad Sandusky1
? 1Physicians Committee for Responsible Medicine, 2The Dow Chemical Company, USA - The usage of Daphnia magna as alternative bioobject in ecotoxicology
Valerii Tonkopii and Irina Iofina
? Institute of Limnology, Russia - Eco-toxicological effect of polycyclic musks for C. elegans
Taiki Mori1, Ayako Inokuchi1, Moritoshi Nihira1, Ryoko Yamamoto1, Hiroshi Ishibashi1, Shinya Kohra2, Nobuaki Tominaga3??and Koji Arizono1
?? 1Prefectural University of Kumamoto, 2Nagasaki University, 4Ariake National College of Technology, Japan - Three Rs achievements in vaccinology
Coenraad Hendriksen
? Netherlands Vaccine Institute and Utrecht University, The Netherlands - Alternatives to the LD50 assay for botulinum toxin potency testing: Strategies and progress towards refinement, reduction and replacement
Dorothea Sesardic and Rose Gaines Das
? National Institute for Biological Standards and Control, UK - 10 years of experience with alternative pyrogen tests (monocyte activation tests)
Ingo Spreitzer, Bettina L?schner, Christian K. Schneider, Kay-Martin Hanschmann and Thomas Montag
? Federal Agency for Sera and Vaccines, Germany - Alternative methods for animal tests in the quality control of biological products in China
Zhengming He
? National Institute for the Control of Pharmaceutical and Biological Products, China - The importance of supplier qualification for vendors of materials used in in vitro assays
Amanda K. Ulrey, Rodger D. Curren and Hans A. Raabe
? Institute for In Vitro Sciences, Inc., USA - Development of defined medium for mouse, monkey and human ES cell culture
Miho Kusuda Furue1, Jie Na3, Jamie P. Jackson3, Takamichi Miyazaki2, Kei Takada2, Hirofumi Suemori2,
? Ryu-Ichiro Hata1, Norio Nakatsuji2, Tetsuji Okamoto4, J. Denry Sato5??and Peter W. Andrews3
? 1Kanagawa Dental College, Japan, 2Kyoto University, Japan, 3The University of Sheffield, UK,
? 4Hiroshima University, Japan, 5Mount Desert Island Biological Laboratory, USA - Chromatin remodelling, a novel strategy to expedite the hepatic differentiation of adult bone marrow stem cells in vitro
Joery De Kock, Tamara Vanhaecke, Vera Rogiers and Sarah Snykers
? Vrije Universiteit Brussel, Belgium - Histone deacetylase inhibitors: Opening a new field of research in the development of alternative methods?
Vera Rogiers, Mathieu Vinken, Sarah Snykers, Tom Henkens, Joanna Fraczek, Evelien De Rop, Joery De Kock, Tatyana Doktorova, Aneta Lukaszuk, Dirk Tourw? and Tamara Vanhaecke
? Vrije Universiteit Brussel, Belgium - Development of a disposable three-compartment micro-cell culture device for toxicokinetic study in humans and its preliminary evaluation
Hidenari Nakayama, Hiroshi Kimura, Kikuo Komori, Teruo Fujii and Yasuyuki Sakai
University of Tokyo, Japan - ToxCastTM: Developing predictive signatures for chemical toxicity
Robert J. Kavlock1, David J. Dix1, Keith A. Houck1, Richard S. Judson2, Matt T. Martin1?and Ann M. Richard1
? 1US Environmental Protection Agency, 2University of North Carolina, USA - Impact of systems toxicology on the 3 Rs
James C. Fuscoe
? U.S. Food and Drug Administration, USA - Percellome toxicogenomics project and its possible contribution to 3R?s
Jun Kanno
? National Institute of Health Sciences, Japan - In vitro assays for evaluating the cellular responses to DNA damage induced by solar UV
Tsukasa Matsunaga
? Kanazawa University, Japan - A quantitative in vitro assay to detect biological activity of endotoxin using rabbit peripheral blood
Masaki Ochiai, Akihiko Yamamoto, Michiyo Kataoka, Hiromi Toyoizumi, Yoshichika Arakawa and Yoshinobu Horiuchi
? National Institute of Infectious Diseases, Japan - A clinically relevant in vitro pyrogen test using a human cell line that have the similar responsiveness to various pyrogens to that of human peripheral blood cells (hPBC)
Akihiko Yamamoto, Masaki Ochiai, Kazunari Kamachi, Michiyo Kataoka, Hiromi Toyoizumi, Yoshichika Arakawa and Yoshinobu Horiuchi
? National Institute of Infectious Diseases, Japan - Effects of experimental alloys containing indium for dental use in vitro embryotoxicity test
Koichi Imai and Masaaki Nakamura
? Osaka Dental University, Japan - An advanced in vitro liver tissue model by combination of on-site oxygenation and double-layer coculture with fibroblasts
Masaki Nishikawa, Nobuhiko Kojima, Takatoki Yamamoto, Teruo Fujii and Yasuyuki Sakai
? University of Tokyo, Japan - Liver cells culture on three-dimensional micropatterned polydimethylsiloxane surfaces
Fanny Evenou, Teruo Fujii and Yasuyuki Sakai
? University of Tokyo, Japan - Development of the alternative method for renal drug excretion using Xenopus oocyte expression system combined with a high throughput method, OOCYTEXPRESS?
Naoko Ohtsu1, Jun Otomo2, Naohiko Anzai3, Takeshi Sakata1, Promsuk Jutabha1, Shinichi Narikawa1,
? Toshihito Kadota1?and Hitoshi Endou1,3,4
? 1Fuji Biomedix Co., Ltd., 2Hitachi, Ltd., 3Kyorin University, 4?J-Pharma Co. Ltd., Japan - A higher throughput method to the Embryonic Stem cell Test (EST), to detect embryotoxicity in early development
Annelieke K. Peters, Margino Steemans, Natalie Mesens, Erik Hansen, Geert R. Verheyen, Steven Spanhaak, Werner Coussement and Philippe Vanparys
? Johnson & Johnson Pharmaceutical Research & Development, Belgium - The possibility of the prediction of slimming by in vitro tests combination
Muneo Tsukiyama1, Yuko Ito1, Noriko Nakashima1, Chinami Urata1, Masaki Arashima1, Hidenobu Okumura1?and Akiyoshi Takada2
? 1NOEVIR, Co. Ltd., 2Osaka University, Japan - Establishment and characterization of a tracheal epithelial cell line RTEC11 from transgenic rats harboring temperature-sensitive simian virus 40 large T-antigen
Takeshi Doi1, Ichiro Takasaki1, Ri-ichi Takahashi2, Masatsugu Ueda2, Yoshihisa Suzuki3, Masuo Obinata3?and Yoshiaki Tabuchi1
? 1University of Toyama, 2The YS Institute, Inc., 3Tohoku University, Japan - Development of an effective three dimensional fabrication technique using inkjet technology
for tissue model samples
Chizuka Henmi1, Makoto Nakamura1,2, Yuichi Nishiyama1, Kumiko Yamaguchi2, Shuichi Mochizuki3,
? Koki Takiura4?and Hidemoto Nakagawa1
1Kanagawa Academy of Science and Technology, 2Tokyo Medical and Dental University, 3Osaka Institute of Technology, 4Yamagata University, Japan - Histological study of pseudobranch in Ctenopharyngodon idella
Gholamreza Hamidian and Naeem Alboghobeish
? Shahid Chamran University of Ahvaz, Iran - Initial study on the safety test using the planarian regeneration
Sakiko Okumura and Yasuhiko Kobayashi
? Shiga-prefectural Yokaichi High School, Japan - HL-60 ATP assay for predicting rat oral toxicity study
Yumiko Iwase and Naohisa Tsutsui
? Mitsubishi Tanabe Pharma Corporation, Japan - Thought before action?What do the public and others really want to know?
Jon Richmond
? Home Office, UK - Severity assessment ? The New Zealand experience and perspective
A.C. David Bayvel, Linda A. Carsons and Kate E. Littin
? Ministry of Agriculture and Forestry, New Zealand - Categories of invasiveness?A precautionary approach
Gilly Griffin, Maryse Dansereau and Cl?ment Gauthier
? Canadian Council on Animal Care, Canada - Attitudes to severity assessment in Japan
Takatoshi Kuhara
? Juntendo University School of Medicine, Japan - Animal welfare and ISO?the International Organisation for Standardization
Jon Richmond
? Home Office, UK - The role of the World Organisation for Animal Health (OIE) in the development of international standards for laboratory animal welfare
Sarah Kahn
? World Organisation for Animal Health, France - Setting global standards for animal welfare monitoring of external contractors
Lars F. Mikkelsen, Helle N. Hansen, Lise Holst and Jan L. Ottesen
? Novo Nordisk A/S, Denmark - A global vision for laboratory animal medicine
Judy MacArthur Clark
International Association of Colleges of Laboratory Animal Medicine, USA - Practical consideration of 3Rs? reduction principle in a private sector CRO on Taiwan
Hans Hsienchuan Chen, Chengnan Yang, Wenchi Jian and Sewfen Leu
? Greenseasons Biotech Co., Ltd., Taiwan - The past to present animal use and current animal protection law in Taiwan
Hans Hsienchuan Chen
? BitotechPath Consulting, Ltd., Taiwan - Animal care and use programs: Global harmonization through alternatives
Kathryn Bayne
? AAALAC International, USA - Necessity of world annual report and country's ranking in commitment to 3Rs; A novel proposition
Fatemeh Heidary1, Reza Gharebaghi1, Mohammad Reza Vaez Mahdavi2, Amir Dibaei3??and Hasan Ghasemi2
?? 1Middle East Breast Cancer Institute, 2Shahed University, Medical School, 3Ahvaz University of Medical Sciences, Iran - The 3 ?R?s approach to marine biotoxin testing in the UK
Ngaire Dennison and David B. Anderson
? Animals (Scientific Procedures) Inspectorate, UK - Incentives and impediments to adopting alternative shellfish testing methods in Canada
Allison Guy and Gilly Griffin
? Canadian Council on Animal Care, Canada - The European partnership for alternative approaches to animal testing
Charles Laroche1, Georgette Lalis2?and Cornelis Brekelmans2
?? 1Unilever, 2European Commission, Belgium - Implementation of the 3Rs in European regulation? activities of Working Group 4 of the European Partnership for Alternative Approaches to Animal Testing: I. Impact of liability issues and the precautionary principle, II. Evaluation of statistical reporting for measuring the uptake of 3Rs in regulatory testing
Julia Scheel1?and Cornelis Brekelmans2
?? 1Henkel KGaA, Germany, 2European Commission, DG ENTR, Belgium - Overview of the test requirements in the area of food and feed safety
Daniela Maurici1, Susan Barlow2, Diane Benford2, Erik Dybing2, Marlies Halder2?, Susanna Louhimies2, Marcelle Holloway2, Antonio Lacerda2, Alberto Mantovani2, Otto Meyer2?, Iona Pratt2, David Morton2, Willem Seinen2, Horst Spielmann2?and Pierre Le Neindre2
? 1EFSA, 2Working group of the EFSA's Scientific Committee on the Welfare of the
? Experimental Animals, Italy - Underreporting of the three Rs deployment that occurs during the planning of protocols that precedes their submission to animal ethics committees
David J. Mellor1, John C. Schofield2?and Virginia M. Williams3
? 1Massey University, 2Otago University, 3Mt Admiral, New Zealand - Risk assessment in animal welfare?EFSA approach
Christine M?eller-Graf1, Denise Candiani2, Sara Barbieri2, Oriol Rib?2, Ana Afonso2, Elisa Aiassa2, Per Have2, Sandra Correia2, Fabrizio De Massis2, Thomasz Grudnik2?and Jordi Serratosa2
? 1Federal Institute for Risk Assessment, Germany, 2European Food Safety Authority, Europe - The extended 1-generation study (OECD 415), as a replacement of the mammalian 2-generation
study (OECD 416)
Horst Spielmann and Richard Vogel
? National Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments,
? Germany - Alternative testing?The intelligent way to REACH compliance
Albrecht Poth and Martina Jaeger
? RCC Cytotest Cells Research GmbH, Germany - Legislation of animal use?Developments in Europe
Bert van Zutphen
? Utrecht University, The Netherlands
| MeetingS | - In Vitro Toxicology Society Drug Transporters Meeting
November 4, 2009
Liverpool, UK - Implementation of the U.S. National Research Council Report on Toxicity Testing in the 21st Century: Can We Make the Business Case for Alternatives? Symposium at Univ. of Chicago Law School
November 5, 2009
Chicago, IL - AALAS National Meeting 2009
November 8-12, 2009
Denver, Colorado USA - CAAT Chemical Information Day
November 11, 2009
Baltimore, MD USA - NC3Rs Workshop: Novel Approaches to Safety Assessment
November 11-12, 2009
London, UK - Japanese Society for Alternatives to Animal Experiments (JSAAE) 22nd Annual Meeting
November 13-15, 2009
Osaka, Japan - FRAME 40th Anniversary Event: Drug Discovery and Development in the 21st Century
November 19, 2009
London, UK - SCAW Winter Conference
December 7-8, 2009
San Antonio, TX - 49th Annual SOT Meeting and ToxExpo
March 7-11, 2010
Salt Lake City, Utah
More Meetings... |
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